MI-3 (Menin-MLL Inhibitor)

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Cas number

1271738-59-0
Chemical s molecular weight

375.55
Chemical s main applications

MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.
Chemical s category

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Other name

4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)-thieno[2,3-d]pyrimidine;
Chemical s formula

C18H25N5S2
Physical properties

No Data Available
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

No Data Available
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

MI-3 Menin-MLL Inhibitor
Gene symbol

KMT2A, MITF, CHD4, MIER1, CHD3, MIR1302-3, MIR509-3, MIR7-3, PIRC14
Short name

MI-3 (Menin-MLL Inhibitor)
Alternative name

MI-3 (Menin-myeloid/lymphoid and mixed-lineage leukemia (trithorax homolog, Drosophila) suppressor)
Alternative to gene target

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), ALL-1 and CXXC7 and HRX and HTRX1 and MLL and MLL/GAS7 and MLL1 and MLL1A and TET1-MLL and TRX1 and WDSTS, MLL and IDBG-73725 and ENSG00000118058 and 4297, lysine-acetylated histone binding, nuclei, Mll1 and IDBG-158453 and ENSMUSG00000002028 and 214162, MLL and IDBG-631302 and ENSBTAG00000018093 and 508330

Identity

HGNC:7132
Gene

KMT2A
Long gene name

lysine methyltransferase 2A
Synonyms gene
- MLL
Synonyms gene name
- myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog)
- myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
- lysine (K)-specific methyltransferase 2A
Synonyms
- TRX1
- HRX
- ALL-1
- HTRX1
- CXXC7
- MLL1A
Synonyms name
- Histone-lysine N-methyltransferase 2A
GenBank acession
- L04284
Locus

11q23.3
Discovery year

1991-11-15
Entrez gene record

4297
Pubmed identfication
- 1720549
RefSeq identity
- NM_005933
Classification
- PHD finger proteins
- SET domain containing
- Lysine methyltransferases
- Zinc fingers CXXC-type
- Bromodomain containing
VEGA ID

OTTHUMG00000166337
Locus Specific Databases
- LRG_613

Identity

HGNC:7105
Gene

MITF
Long gene name

melanocyte inducing transcription factor
Synonyms gene
- WS2A
- WS2
Synonyms gene name
- Waardenburg syndrome, type 2A
- microphthalmia-associated transcription factor
- melanogenesis associated transcription factor
Synonyms
- MI
- bHLHe32
Synonyms name
- homolog of mouse microphthalmia
Locus

3p13
Discovery year

1993-10-27
Entrez gene record

4286
Pubmed identfication
- 8069297
- 7874167
- 7951321
RefSeq identity
- NM_198159
Classification
- Basic helix-loop-helix proteins
VEGA ID

OTTHUMG00000149921
Locus Specific Databases
- Global Variome shared LOVD
- LRG_776

Identity

HGNC:1919
Gene

CHD4
Long gene name

chromodomain helicase DNA binding protein 4
Synonyms
- Mi-2b
- Mi2-BETA
GenBank acession
- X86691
Locus

12p13.31
Discovery year

1998-03-20
Entrez gene record

1108
Pubmed identfication
- 7575689
- 27235397
RefSeq identity
- NM_001273
Classification
- NuRD complex subunits
- PHD finger proteins
- Small nucleolar RNA protein coding host genes
VEGA ID

OTTHUMG00000169164

Identity

HGNC:29657
Gene

MIER1
Long gene name

MIER1 transcriptional regulator
Synonyms gene name
- mesoderm induction early response 1 homolog (Xenopus laevis)
- mesoderm induction early response 1, transcriptional regulator
Synonyms
- hMI-ER1
- MI-ER1
- KIAA1610
Locus

1p31.3
Discovery year

2005-07-14
Entrez gene record

57708
Pubmed identfication
- 12242014
- 12482978
RefSeq identity
- NM_020948
Classification
- Myb/SANT domain containing
VEGA ID

OTTHUMG00000009194

Identity

HGNC:1918
Gene

CHD3
Long gene name

chromodomain helicase DNA binding protein 3
Synonyms
- Mi-2a
- ZFH
- Mi2-ALPHA
GenBank acession
- U08379
Locus

17p13.1
Discovery year

1998-03-20
Entrez gene record

1107
Pubmed identfication
- 9326634
- 7560064
RefSeq identity
- NM_001005273
Classification
- Small nucleolar RNA protein coding host genes
- NuRD complex subunits
- PHD finger proteins
VEGA ID

OTTHUMG00000150427