EML4/ALK FISH Probe

Description

any of various testing devices or substances as (1) a pointed metal tip for making electrical contact with a circuit element being checked (2) a usually small object that is inserted into something so as to test conditions at a given point (3) a device used to penetrate or send back information especially from outer space or a celestial body (4) a device (as an ultrasound generator) or a substance (as radioactively labeled DNA) used to obtain specific information for diagnostic or experimental purposes

Gene target

EML4/ALK FISH
Gene symbol

EML4-AS1, EML4, SH3PXD2A, ALK, ENPP7, TGFBR1, BMPR2
Short name

EML4/ALK FISH Probe
Technique

probe, probes
Species

Fish, Fishes
Alternative name

EML4/anaplastic lymphoma receptor tyrosine kinase fluorescence-emitting hybridization Probe
Alternative technique

probes
Alternative to gene target

anaplastic lymphoma receptor tyrosine kinase, CD246 and NBLST3, ALK and IDBG-42084 and ENSG00000171094 and 238, transferase activity, Plasma membranes, Alk and IDBG-197259 and ENSMUSG00000055471 and 11682, ALK and IDBG-636042 and ENSBTAG00000007379 and 536642

Identity

HGNC:427
Gene

ALK
Long gene name

ALK receptor tyrosine kinase
Synonyms gene name
- anaplastic lymphoma kinase (Ki-1)
- anaplastic lymphoma receptor tyrosine kinase
Synonyms
- CD246
- ALK1
GenBank acession
- D45915
Locus

2p23.2-p23.1
Discovery year

1993-08-24
Entrez gene record

238
Pubmed identfication
- 8122112
RefSeq identity
- NM_004304
Classification
- Receptor tyrosine kinases
- CD molecules
VEGA ID

OTTHUMG00000152034
Locus Specific Databases
- LRG_488

Identity

HGNC:11772
Gene

TGFBR1
Long gene name

transforming growth factor beta receptor 1
Synonyms gene
- MSSE
- ESS1
Synonyms gene name
- multiple self-healing squamous epithelioma
- transforming growth factor beta receptor I
Synonyms
- ALK-5
- ACVRLK4
- ALK5
- TBRI
- TBR-i
Synonyms name
- activin A receptor type II-like kinase, 53kDa
Locus

9q22.33
Discovery year

1993-09-30
Entrez gene record

7046
Pubmed identfication
- 1319842
- 8530052
- 21358634
Classification
- Type 1 receptor serine/threonine kinases
VEGA ID

OTTHUMG00000020353
Locus Specific Databases
- LOVD - Center for Medical Genetics, Ghent, Belgium

Identity

HGNC:1078
Gene

BMPR2
Long gene name

bone morphogenetic protein receptor type 2
Synonyms gene
- PPH1
Synonyms gene name
- primary pulmonary hypertension 1
- bone morphogenetic protein receptor, type II (serine/threonine kinase)
- bone morphogenetic protein receptor type II
Synonyms
- BRK-3
- T-ALK
- BMPR3
- BMPR-II
GenBank acession
- Z48923
Locus

2q33.1-q33.2
Discovery year

1997-03-19
Entrez gene record

659
Pubmed identfication
- 7791754
RefSeq identity
- NM_001204
Classification
- Type 2 receptor serine/threonine kinases
VEGA ID

OTTHUMG00000133617
Locus Specific Databases
- LRG_712

Name

In Situ Hybridization
Concept

Scope note: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Tree numbers
- E01.370.225.500.620.670.325
- E01.370.225.750.600.670.325
- E05.200.500.620.670.325
- E05.200.750.600.670.325
- E05.393.661.475
Qualifiers

ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data