CDKN2A Antibody (phospho-S8)

• Catalog number
  F48749-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CDKN2A (phospho-S8)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  DB, ELISA
• Recommended dilutions
  Dot blot: 1:500
• Notes
  Titration of the phospho-CDKN2A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This phospho-CDKN2A antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P42771
• Purity
  Antigen affinity
• Description
  This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
• Immunogen
  This phospho-CDKN2A antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS8 of human CDKN2A.
• Storage
  Aliquot the phospho-CDKN2A antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CDKN2A   phospho-S8  
• Gene symbol
  RPS8, PSMC5, CDKN2A-DT, CDKN2A
• Short name
  Anti-CDKN2A (phospho-S8)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to CDKN2A (phospho-S8)
• Alternative technique
  antibodies
• Alternative to gene target
  cyclin-dependent kinase inhibitor 2A, ARF and CDK4I and CDKN2 and CMM2 and INK4 and INK4A and MLM and MTS-1 and MTS1 and P14 and P14ARF and P16 and P16-INK4A and P16INK4 and P16INK4A and P19 and P19ARF and TP16, CDKN2A and IDBG-54547 and ENSG00000147889 and 1029, MDM2/MDM4 family protein binding, nuclei, CDKN2A and IDBG-630043 and ENSBTAG00000034220 and 616369

Gene info

• Identity
  HGNC:10441
• Gene
  RPS8
• Long gene name
  ribosomal protein S8
• Synonyms
  • S8
• GenBank acession
  • BC070875
• Locus
  1p34.1
• Discovery year
  1992-07-20
• Entrez gene record
  6202
• Pubmed identfication
  • 8432552
• RefSeq identity
  • NM_001012
• Classification
  • Small nucleolar RNA protein coding host genes
  • S ribosomal proteins
• VEGA ID
  OTTHUMG00000008494

Gene info

• Identity
  HGNC:9552
• Gene
  PSMC5
• Long gene name
  proteasome 26S subunit, ATPase 5
• Synonyms gene name
  • proteasome (prosome, macropain) 26S subunit, ATPase, 5
• Synonyms
  • SUG1
  • p45/SUG
  • TBP10
  • p45
  • S8
  • TRIP1
  • SUG-1
  • RPT6
• GenBank acession
  • L38810
• Locus
  17q23.3
• Discovery year
  1995-12-08
• Entrez gene record
  5705
• Pubmed identfication
  • 9473509
  • 9048938
• RefSeq identity
  • NM_002805
• Classification
  • Proteasome
  • AAA ATPases
• VEGA ID
  OTTHUMG00000179013

Gene info

• Identity
  HGNC:23831
• Gene
  CDKN2A-DT
• Long gene name
  CDKN2A divergent transcript
• Synonyms gene
  • C9orf53
  • CDKN2A-AS1
• Synonyms gene name
  • chromosome 9 open reading frame 53
  • CDKN2A antisense RNA 1 (head to head)
• Synonyms
  • bA149I2.3
• GenBank acession
  • AF211119
• Locus
  9p21.3
• Discovery year
  2004-07-23
• Entrez gene record
  51198
• RefSeq identity
  • NR_024274
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000019687

Gene info

• Identity
  HGNC:1787
• Gene
  CDKN2A
• Long gene name
  cyclin dependent kinase inhibitor 2A
• Synonyms gene
  • CDKN2
  • MLM
• Synonyms gene name
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
• Synonyms
  • CDK4I
  • p16
  • INK4a
  • MTS1
  • CMM2
  • ARF
  • p19
  • p14
  • INK4
  • p16INK4a
  • p19Arf
  • p14ARF
• GenBank acession
  • L27211
• Locus
  9p21.3
• Discovery year
  1994-05-19
• Entrez gene record
  1029
• Pubmed identfication
  • 8152487
  • 7606716
• RefSeq identity
  • NM_000077
• VEGA ID
  OTTHUMG00000019686
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_11

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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