Anti-KLK6 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-5870R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  KLK6
• Specificity
  This antibody reacts specifically with KLK6
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Cytoplasm, Nucleus, Secreted, Mitochondrion
• Antigen Source
  KLH conjugated synthetic peptide derived from human KLK6
• Gene ID
  5653
• Swiss Prot
  Q92876
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  hK6; Bssp; Klk7; SP59; PRSS9; PRSS18; Kallikrein-6; Neurosin; Protease M; Serine protease 18; Serine protease 9; Zyme; KLK6
• Also known as
  KLK6 Polyclonal Antibody
• Other name
  Anti-KLK6 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  KLK6  
• Gene symbol
  KLK1, KLK6
• Short name
  Anti-KLK6
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  KLK6 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:6357
• Gene
  KLK1
• Long gene name
  kallikrein 1
• Synonyms gene name
  • kallikrein 1, renal/pancreas/salivary
• Synonyms
  • Klk6
• GenBank acession
  • L10038
• Locus
  19q13.33
• Discovery year
  1988-06-27
• Entrez gene record
  3816
• Pubmed identfication
  • 1684954
  • 16800724
  • 16800723
• RefSeq identity
  • NM_002257
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000182876

Gene info

• Identity
  HGNC:6367
• Gene
  KLK6
• Long gene name
  kallikrein related peptidase 6
• Synonyms gene
  • PRSS9
  • PRSS18
• Synonyms gene name
  • protease, serine, 18
  • kallikrein 6 (neurosin, zyme)
• Synonyms
  • Bssp
  • Klk7
  • neurosin
• GenBank acession
  • U62801
• Locus
  19q13.41
• Discovery year
  1997-06-09
• Entrez gene record
  5653
• Pubmed identfication
  • 9003450
  • 16800724
  • 16800723
• RefSeq identity
  • NM_002774
• Classification
  • Kallikreins
  • Serine proteases
• VEGA ID
  OTTHUMG00000183098

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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