GDF-15-D, human recombinant

• Catalog number
  4570-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  MIC1, PDF, PLAB, PTGFB
• Alternative_names
  MIC-1, Placental TGFβ, Prostate differentiation factor
• Description
  A protein with functions in regulating inflammatory and apoptotic pathways
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Biological activity
  The activity is determined by the inhibition of DU-145 cells and is typically 1-2 µg/ml.
• Results
  1-2 µg/ml
• Molecular Weight
  26.8 kDa
• Storage Temp
  -20°C
• Shipping
  Blue ice
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and lyophilized with no additives
• Reconstitution Instructions
  Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 5 mM acetic acid at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
• Background Information
  Growth and differentiation factor 15 (GDF-15) is a TGFβ family member, made by in the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an immerging marker of early heart disease and has the potential as being used as a molecule for screening patients for early heart failure. Recombinant human GDF-15 (D-variant) is a non-glycosylated, disulfide linked homodimer. It is comprised of two identical 120 amino acid monomers and has a total molecular mass of 26.8 kDa. There is a His to an Asp substitution at position 7.
• Amino acid sequence
  MARNGDDCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  GDF-15-D  
• Gene symbol
  PIRC66, PIRC71, PIRC75, PIRC67, PIRC72, PIRC68, PIRC62, SNAR-D, PIRC70, PIRC76
• Short name
  GDF-15-D, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  GDF-15-D, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:37570
• Gene
  PIRC66
• Long gene name
  piwi-interacting RNA cluster 66
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313865
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37575
• Gene
  PIRC71
• Long gene name
  piwi-interacting RNA cluster 71
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313818
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37579
• Gene
  PIRC75
• Long gene name
  piwi-interacting RNA cluster 75
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313919
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37571
• Gene
  PIRC67
• Long gene name
  piwi-interacting RNA cluster 67
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313817
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37576
• Gene
  PIRC72
• Long gene name
  piwi-interacting RNA cluster 72
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313867
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37572
• Gene
  PIRC68
• Long gene name
  piwi-interacting RNA cluster 68
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313931
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37566
• Gene
  PIRC62
• Long gene name
  piwi-interacting RNA cluster 62
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313816
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:34324
• Gene
  SNAR-D
• Long gene name
  small NF90 (ILF3) associated RNA D
• Synonyms gene name
  • small ILF3/NF90-associated RNA D
• GenBank acession
  • EU071071
• Locus
  19q13.33
• Discovery year
  2008-07-03
• Entrez gene record
  100170227
• Pubmed identfication
  • 17855395
• RefSeq identity
  • NR_024243
• Classification
  • Small NF90 (ILF3) associated RNAs

Gene info

• Identity
  HGNC:37574
• Gene
  PIRC70
• Long gene name
  piwi-interacting RNA cluster 70
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313866
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37580
• Gene
  PIRC76
• Long gene name
  piwi-interacting RNA cluster 76
• Locus
  15
• Discovery year
  2009-11-05
• Entrez gene record
  100313796
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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