anti-CARMA3 Antibody

• Catalog number
  3193
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  CARMA3 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein binds to BCL10 and activates NF-kB Recent experiments have shown that CARMA3 is required for EGF-induced NF-kB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
• Gene names
  CARMA3 Antibody: BIMP1, CARMA3, Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3
• Antibodie s label
  unlabelled serum
• Purity
  CARMA3 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  CARMA3 antibody is human specific. At least three isoforms of CARMA3 are known to exist; this antibody will only detect isoform 1. CARMA3 antibody is predicted not to cross-react with other CARMA proteins.
• Antigen
  CARMA3 antibody was made against a 16 amino acid synthetic peptide near the amino terminus of human CARMA3.
• Immuno application
  ELISA, immuno-histo-chemistry
• Antibody advice
  CARMA3 antibody can be used for detection of CARMA3 by immunohistochemistry at 5 ug/mL.
• Suspention pH azide
  CARMA3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  CARMA3 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  51093861
• Ncbi nr
  NP_055365
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  29775
• GENE symbol
  CARD10
• Antigene name
  caspase recruitment domain family, member 10
• Source
  Homo sapiens
• Protein nr
  Q9BWT7
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CARMA3  
• Gene symbol
  CARD10
• Short name
  anti-CARMA3 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toCARMA3 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16422
• Gene
  CARD10
• Long gene name
  caspase recruitment domain family member 10
• Synonyms gene name
  • caspase recruitment domain family, member 10
• Synonyms
  • CARMA3
  • BIMP1
• GenBank acession
  • AF086324
• Locus
  22q13.1
• Discovery year
  2002-09-19
• Entrez gene record
  29775
• Pubmed identfication
  • 11259443
  • 11356195
• RefSeq identity
  • NM_014550
• Classification
  • Membrane associated guanylate kinases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000150592

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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