Rabbit Anti-Human ROR2 (pTyr645 + pTyr646) Polyclonal: RPE
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Catalog numberSPC-1075D-RPE
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PricePlease ask
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Size100 µl
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ImmunogenA phospho-specific peptide corresponding to residues surrounding Tyr645 and Tyr646 of human ROR2 (AA642-649)
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Antibody s targetHuman ROR2 (pTyr645 + pTyr646)
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Antibody s full descriptionRabbit Anti-Human ROR2 (pTyr645 + pTyr646) Polyclonal
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Antibody s categoryPolyclonal Antibodies
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Antibody s other nameNTRKR2 Antibody, Receptor tyrosine kinase-like orphan receptor 2 Antibody, receptor-related 2 Antibody, ROR2 Antibody, ROR2_HUMAN Antibody, Tyrosine protein kinase transmembrane receptor ROR2 Antibody, Tyrosine-protein kinase transmembrane receptor Ror2 Antibody, BDB Antibody, BDB1 Antibody, Brachydactyly type B Antibody, EC 2.7.10.1 Antibody, MGC163394 Antibody, Neurotrophic tyrosine kinase Antibody, Neurotrophic tyrosine kinase, receptor related 2 Antibody
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Verified applicationsWB, AM
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Raised inRabbit
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Antibody s reactivityHuman
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Antibody s recommended dilutions for useWB (1:250); optimal dilutions for assays should be determined by the user.
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Antibody s purified fromPeptide Affinity Purified
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Recommended buffer for storagePBS pH7.4, 50% glycerol, 0.025% Thimerosal
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Antibody s concentrationSee included datasheet or contact our support service
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Antibody s specificityDetects 104.757 kDa.
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Storage recommendations-20°C
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Shipping recommendationsBlue Ice or 4°C
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Certificate of analysisA 1:250 dilution of SPC-1075 was sufficient for detection of ROR2 (pTyr645 + pTyr646) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
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Antibody in cellCell Membrane
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Tissue specificityHighly expressed during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
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Scientific contextROR2 is a receptor tyrosine kinase which may have a role in early cartilage and growth plate development. ROR2 expression is generally highest during embryonic development and will gradually decrease as cells terminally differentiate. Wnt5a has been identified to utilize ROR2 as a co-receptor for non-canonical Wnt signalling. Aberrant expression of ROR2 has been implicated in gastric, osteosarcoma, mestatic melanoma, prostate, renal cell and squamous cell carcinomas. Increased expression of ROR2 was correlated with increased metastasis. In prostate, osteosarcomas and metastatic melanomas, Wnt5a/ROR2 receptor complex formation was implicated as the mechanism for cancer progression. ROR2 seems to function as an oncogene. Primarily mis-sense mutations of ROR2 have been identified in tumours but their functional effect has not been well characterized.
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BibliographyRefer to PubMed
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Released date29/Aug/2016
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NCBI numberNP_004551
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Gene number4920
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Protein numberQ01974
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Antibody s datasheetContact our support service to receive datasheet or other technical documentation.
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Representative figure linkNo Data Available
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg1.4
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Net weight g0.1
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Stock availabilitIn Stock
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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TestStressMark antibodies supplies antibodies that are for research of human proteins.
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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GroupPolyclonals and antibodies
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AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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Gene target
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Gene symbolRPE, ROR2, RORA
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Short nameRabbit Anti- ROR2 (pTyr645 + pTyr646) Polyclonal: RPE
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Techniqueanti-Human, Polyclonal, Rabbit, anti-, anti, antibody to, antibodies, antibodies against human proteins, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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HostRabbit, Rabbits
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IsotypeImmunoglobulin
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LabelRPE
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SpeciesHuman, Humans
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Alternative nameproduction species: rabbit Antibody toHuman ROR2 (pTyr645 + pTyr646) polyclonal: RPE
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Alternative techniquepolyclonals, rabbit-anti, antibodies
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Gene info
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Identity
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Gene
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Long gene nameribulose-5-phosphate-3-epimerase
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namereceptor tyrosine kinase like orphan receptor 2
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Synonyms gene
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Synonyms gene name
- receptor tyrosine kinase-like orphan receptor 2
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GenBank acession
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Locus
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Discovery year2000-02-29
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Entrez gene record
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Pubmed identfication
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Classification
- Receptor tyrosine kinases
- I-set domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameRAR related orphan receptor A
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Synonyms gene name
- RAR-related orphan receptor A
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-04-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RAR related orphan receptors
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data