TG003, Clk family kinase inhibitor

• Catalog number
  SIH-515-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  719277-26-6
• Description
  Clk family kinase inhibitor
• Molecular weight
  249,3 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  TG 003, (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C13H15NO2S
• Origin
  Synthetic
• Purity pourcentage
  >98 %
• Soluble in
  Soluble to 100 mM in DMSO and to 75 mM in ethanol
• Physical appearance
  Yellow solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  1893668
• Scientific context
  TG003 is a potent inhibitor of the CDC-like (Clk) family kinases. It has been shown to suppress serine/arginine-rich protein phosphorylation.
• Bibliography
  1. Muraki M., et al. (2004) J. Biol. Chem. 279(23): 24246–24254.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of TG003 (SIH-515), a Clk family kinase inhibitor. CAS #: 719277-26-6. Molecular Formula: C13H15NO2S. Molecular Weight: 249.3 g/mol. Chemical structure of TG003, a Clk family kinase inhibitor (SIH-515). CAS # 719277-26-6. Molecular Formula: C13H15NO2S.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  TG003   Clk   family   kinase   inhibitor  
• Short name
  TG003, Clk family kinase inhibitor
• Alternative name
  TG003, Clk family phosphorylation catalyst suppressor

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