Leptin, Rat

Data Sheet URL
Gene

Human or mouse Leptin (from Greek λεπτός leptos, "thin") the "satiety hormone", is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis. ELISA kits and peptides and antibodies are available.
About

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name

Rattus norvegicus

Identity

HGNC:6553
Gene

LEP
Long gene name

leptin
Synonyms gene
- OBS
- OB
Synonyms gene name
- leptin (murine obesity homolog)
- leptin (obesity homolog, mouse)
Locus

7q32.1
Discovery year

1993-01-26
Entrez gene record

3952
Pubmed identfication
- 1686014
- 16932309
Classification
- Neuropeptides
VEGA ID

OTTHUMG00000157564