BIBW 2992, EGFR, HER2 kinase inhibitor

• Catalog number
  SIH-496-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  850140-72-6
• Description
  EGFR, HER2 kinase inhibitor
• Molecular weight
  485,9 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  Afatinib, N-​[4-​[(3-​chloro-​4-​fluorophenyl)amino]-​7-​[[(3S)-​tetrahydro-​3-​furanyl]oxy]-​6-​quinazolinyl]-​4-​(dimethylamino)-​2-​butenamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C24H25ClFN5O3
• Origin
  Synthetic
• Purity pourcentage
  >99%
• Soluble in
  Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml
• Physical appearance
  Crystalline solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Acute Toxicity: Oral, Category 2 Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 1 Toxic To Reproduction, Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300: Fatal if swallowed. H315: Causes skin irritation. H318: Causes serious eye damage. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage through prolonged or repeated exposure. Precautionary statements: P264: Wash {hands} thoroughly after handling. P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth. P302+352: IF ON SKIN: Wash with plenty of soap and water. P332+313: If skin irritation occurs, get medical advice/attention. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a {POISON CENTER/doctor/...}. P308+313: IF exposed or concerned: Get medical attentiodvice. P314: Get medical attentiodvice if you feel unwell.
• PubChem number
  10184653
• Scientific context
  BIBW 2992 is a potent and irreversible ErbB inhibitor. It has also been shown to inhibit EGFR/Neu.
• Bibliography
  1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of BIBW 2992 (SIH-496), a EGFR and HER2 kinase inhibitor. CAS #: 439081-18-2. Molecular Formula: C24H25ClFN5O3. Molecular Weight: 485.9 g/mol. Chemical structure of BIBW 2992, a EGFR and HER2 kinase inhibitor (SIH-496). CAS # 439081-18-2. Molecular Formula: C24H25ClFN5O3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  BIBW   2992   EGFR   HER2   kinase   inhibitor  
• Gene symbol
  EGFR-AS1, EGILA, EGFR, ERBB2, RHBDF1
• Short name
  BIBW 2992, EGFR, HER2 kinase inhibitor
• Alternative name
  BIBW 2992, epidermal growth factor receptor, HER2 phosphorylation catalyst suppressor
• Alternative to gene target
  epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217

Gene info

• Identity
  HGNC:40207
• Gene
  EGFR-AS1
• Long gene name
  EGFR antisense RNA 1
• Locus
  7p11.2
• Discovery year
  2012-11-06
• Entrez gene record
  100507500
• Pubmed identfication
  • 26271667
  • 28920960
• RefSeq identity
  • NR_047551
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000156126

Gene info

• Identity
  HGNC:54482
• Gene
  EGILA
• Long gene name
  EGFR interacting lncRNA
• Synonyms
  • Lnc-EGFR
• Locus
  14q11.2
• Discovery year
  2019-09-27
• Pubmed identfication
  • 28541302
• Classification
  • Long non-coding RNAs with non-systematic symbols

Gene info

• Identity
  HGNC:3236
• Gene
  EGFR
• Long gene name
  epidermal growth factor receptor
• Synonyms gene
  • ERBB
• Synonyms gene name
  • epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
• Synonyms
  • ERBB1
  • ERRP
• Synonyms name
  • erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)
  • erb-b2 receptor tyrosine kinase 1
• Locus
  7p11.2
• Discovery year
  1986-01-01
• Entrez gene record
  1956
• Pubmed identfication
  • 1505215
• RefSeq identity
  • NM_005228
• Classification
  • Erb-b2 receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000023661
• Locus Specific Databases
  • LRG_304

Gene info

• Identity
  HGNC:3430
• Gene
  ERBB2
• Long gene name
  erb-b2 receptor tyrosine kinase 2
• Synonyms gene
  • NGL
• Synonyms gene name
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
• Synonyms
  • NEU
  • HER-2
  • CD340
  • HER2
• Synonyms name
  • neuro/glioblastoma derived oncogene homolog
  • human epidermal growth factor receptor 2
• GenBank acession
  • X03363
• Locus
  17q12
• Discovery year
  2001-06-22
• Entrez gene record
  2064
• RefSeq identity
  • NM_004448
• Classification
  • Erb-b2 receptor tyrosine kinases
  • CD molecules
  • Minor histocompatibility antigens
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000179300
• Locus Specific Databases
  • LRG_724

Gene info

• Identity
  HGNC:20561
• Gene
  RHBDF1
• Long gene name
  rhomboid 5 homolog 1
• Synonyms gene
  • C16orf8
• Synonyms gene name
  • chromosome 16 open reading frame 8
  • rhomboid family 1 (Drosophila)
  • rhomboid 5 homolog 1 (Drosophila)
• Synonyms
  • EGFR-RS
  • FLJ2235
  • Dist1
  • iRhom1
• GenBank acession
  • BC014425
• Locus
  16p13.3
• Discovery year
  2003-04-07
• Entrez gene record
  64285
• Pubmed identfication
  • 8318735
  • 15965977
• RefSeq identity
  • NM_022450
• Classification
  • Rhomboid family
• VEGA ID
  OTTHUMG00000060719

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