EZSolution™ Stat3 Inhibitor I, S3I-201

  • Catalog number
    2541-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    2-Hydroxy-4-[[[[4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid; NSC 74859; S3I-201
  • Description
    Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC₅₀ = 86 ± 33 µM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo.
  • CAS Number
    501919-59-1
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₆H₁₅NO₇S
  • Molecular Weight
    365.36
  • Cell Permeable
    Yes
  • Purity
    ≥97% by HPLC
  • Handling
    Protect from air and moisture
  • Tag Line
    A Stat3 Inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    12months
  • MDL Number
    MFCD09907564
  • PubChem CID
    252682
  • SMILES
    CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
  • InChi
    InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
  • InChi Key
    HWNUSGNZBAISFM-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    OR3A3
  • Short name
    EZSolution™ Stat3 Inhibitor I, S3I-201
  • Alternative name
    EZSolution™ signal transducer and activator on transcription 3 (acute-phase response factor) suppressor I, S3I-201
  • Alternative to gene target
    signal transducer and activator of transcription 3 (acute-phase response factor), ADMIO and APRF and HIES, STAT3 and IDBG-50702 and ENSG00000168610 and 6774, protein dimerization activity, nuclei, Stat3 and IDBG-211637 and ENSMUSG00000004040 and 20848, STAT3 and IDBG-640197 and ENSBTAG00000021523 and 101910056,508541
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