Doramapimod
-
Catalog number1954-25
-
PricePlease ask
-
Size25 mg
-
-
Alternative_name1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
-
DescriptionCell-permeable. A potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.
-
CAS Number285983-48-4
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₃₁H₃₇N₅O₃
-
Molecular Weight527.66
-
Cell PermeableYes
-
Purity≥98% by HPLC
-
SolubilitiesDMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)
-
HandlingProtect from light and moisture
-
Tag LineA potent p38 MAP kinase inhibitor
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life48 months
-
MDL NumberMFCD09752957
-
PubChem CID156422
-
SMILESCC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
-
InChiInChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2, 3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19- 16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
-
InChi KeyMVCOAUNKQVWQHZ-UHFFFAOYSA-N
-
MSDS AvailableYes
-
Gene target
-
Short nameDoramapimod
-
Alternative nameDoramapimod
-