Doramapimod

• Catalog number
  1954-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
• Description
  Cell-permeable. A potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases.  In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.
• CAS Number
  285983-48-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₁H₃₇N₅O₃
• Molecular Weight
  527.66
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A potent p38 MAP kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• MDL Number
  MFCD09752957
• PubChem CID
  156422
• PubChem CID Link
• SMILES
  CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
• InChi
  InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2, 3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19- 16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
• InChi Key
  MVCOAUNKQVWQHZ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Doramapimod  
• Short name
  Doramapimod
• Alternative name
  Doramapimod

Similar products