Rabbit Anti-Human MCSF Receptor (pSer807 + pTyr809) Polyclonal: RPE

  • Catalog number
    SPC-954D-RPE
  • Price
    Please ask
  • Size
    100 µl
  • Immunogen
    A phospho-specific peptide corresponding to residues surrounding Ser807 and Tyr809 of human CSF1R (AA804-813)
  • Antibody s target
    Human MCSF Receptor (pSer807 + pTyr809)
  • Antibody s full description
    Rabbit Anti-Human MCSF Receptor (pSer807 + pTyr809) Polyclonal
  • Antibody s category
    Polyclonal Antibodies
  • Antibody s other name
    C FMS Antibody, CD 115 Antibody, CFMS Antibody, Colony stimulating factor 1 receptor Antibody, CSF 1R Antibody, CSF1R_HUMAN Antibody, FIM 2 Antibody, FMS Antibody, FMS proto oncogene Antibody, HDLS Antibody, Macrophage colony stimulating factor 1 receptor Antibody, MCSFR Antibody
  • Verified applications
    WB, AM
  • Raised in
    Rabbit
  • Antibody s reactivity
    Human
  • Antibody s recommended dilutions for use
    WB (1:250); optimal dilutions for assays should be determined by the user.
  • Antibody s purified from
    Peptide Affinity Purified
  • Recommended buffer for storage
    PBS pH7.4, 50% glycerol, 0.025% Thimerosal
  • Antibody s concentration
    See included datasheet or contact our support service
  • Antibody s specificity
    Detects 107.984 kDa.
  • Storage recommendations
    -20°C
  • Shipping recommendations
    Blue Ice or 4°C
  • Certificate of analysis
    A 1:250 dilution of SPC-954 was sufficient for detection of MCSF Receptor (pSer807 + pTyr809) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
  • Antibody in cell
    Membrane
  • Tissue specificity
    See included datasheet or contact our support service.
  • Scientific context
    Receptor for colony stimulating factor-1 and links CSF 1 signals to Ras-ERK pathway. It is involved in hematopoesis and commits cells to differentiation. Most cancer mutations and chromosomal alterations appear to confer loss of function suggesting that absence of this gene causes hematopoeic malignancy via inability of cells to mature. Point mutations and partial deletions of CSF1R have been observed in acute myeloid leukemia and myelodysplastic syndrome respectively. A chromosomal translocation event leading to fusion of CSF1R to RBM6 has been observed in acute megakaryoblastic leukemia. In women, overexpression of CSF1R has been observed in breast and cervical cancers and is thought to play an autocrine role in stimulating cancer progression. Due to CSF1R role in cell proliferation its main role in cancer progression is likely oncogenic and maybe mediated through dysfunction of regulation of the receptor.
  • Bibliography
    Refer to PubMed
  • Released date
    29/Aug/2016
  • NCBI number
    NP_005202
  • Gene number
    1436
  • Protein number
    P07333
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Antibody s datasheet
    Contact our support service to receive datasheet or other technical documentation.
  • Representative figure link
    No Data Available
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    1.4
  • Net weight g
    0.1
  • Stock availabilit
    In Stock
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Test
    StressMark antibodies supplies antibodies that are for research of human proteins.
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Group
    Polyclonals and antibodies
  • About
    Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • Gene target
    MCSF   Receptor   pSer807   pTyr809   RPE  
  • Gene symbol
    RPE, CSF1
  • Short name
    Rabbit Anti- MCSF Receptor (pSer807 + pTyr809) Polyclonal: RPE
  • Technique
    anti-Human, Polyclonal, Rabbit, anti-, anti, antibody to, antibodies, antibodies against human proteins, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
  • Host
    Rabbit, Rabbits
  • Isotype
    Immunoglobulin
  • Label
    RPE
  • Species
    Human, Humans
  • Alternative name
    production species: rabbit Antibody toHuman MCSF Receptor (pSer807 + pTyr809) polyclonal: RPE
  • Alternative technique
    polyclonals, rabbit-anti, antibodies
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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