Apoptozole

Alternative_name

4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl]methyl]-benzamide, Apoptosis Activator VII
Description

Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively. Apoptozole dose-dependently induces apoptosis in cancer cells (IC₅₀ = 5-7 µM). It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.
CAS Number

1054543-47-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₃H₂₅F₆N₃O₃
Molecular Weight

625.6
Cell Permeable

True
Purity

≥98% by HPLC
Solubilities

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A heat shock protein 70 (Hsp70) inhibitor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

24894064
PubChem CID Link
SMILES

COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC
InChi

InChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)
InChi Key

ZIMMTPFXOMAJTQ-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

True