HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 1 Antibody
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Catalog numberGEN219860
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PricePlease ask
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Size100ug
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Also known asDELTA-LIKE PROTEIN 1
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Other namesdelta-like protein 1; Delta-like protein 1; delta-like protein 1; H-Delta-1; drosophila Delta homolog 1; delta-like 1 (Drosophila); Drosophila Delta homolog 1
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CategoryAntibodies
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SubcategoryMnoclonal antibodies
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Gene nameDLL1; DLL1; DL1; Delta; DELTA1; Delta1; H-Delta-1
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Gene name synonimsDLL1; DLL1; DL1; Delta; DELTA1; Delta1; H-Delta-1
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Other gene namesDLL1; DLL1; DL1; Delta; DELTA1; Delta1; H-Delta-1
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ClonalityMonoclonal
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Immunoglobulin isotypeIgG
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CloneHMD1-5
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Host organismHamster
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Species reactivityMouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivityDELTA-LIKE PROTEIN 1 This item specifically recognises Delta-like protein 1 (DLL1), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. _x000D__x000D_The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. _x000D__x000D_Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. _x000D__x000D_DLL1 is widely expressed, and acts as a mediator of cell fate decisions during haematopoiesis, and may play a role in cell-to-cell communication in mammalian embryos. DLL1 plays an important role in B and T cell differentiation, in embryonic somite formation and patterning, and associates with the scaffolding protein MAGI1 at adherens junctions on neuronal processes. Signalling through DLL1 and Notch 2 has been implicated in the development of marginal zone B cells (MZB). _x000D__x000D_Clone HMD1-5 has been shown to cross-react with rat mast cell line RBL-2H3 in flow cytometry.
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Purification methodN/A
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Form AppearancePurified (Purified IgG - liquid)
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ConcentrationIgG concentration 1.0mg/ml
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Storage and shippingStore the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.
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Tested applicationsFlow Cytometry (FACS), Functional Assay (FA), Immunohistology - Frozen (IHC)
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody.
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PropertiesIf you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Armenian of Syrian hamster monoclonal IgGs are useful antibodies for double staining your IHC samples. Using mabs or monoclonal antibodies has a lot of advantages for Flow cytometry.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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French translationanticorps
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Gene target
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Gene symbolAGPAT4, PSMB6, AHCTF1P1, PPM1D, INGX, PSMA6P1, AFF3, LPAR4, TFDP3, PPP1R1C
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Short nameANTI MOUSE DELTA-LIKE PROTEIN 1 Antibody
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Techniqueanti mouse, Antibody, Mouse, anti, antibody to, anti mouse antibodies, antibodies against human proteins, antibodies for, mouses
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HostHamster
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SpeciesMouse, Hamsters, Mouses
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Alternative nameAnti-HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 1
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Alternative techniqueantibodies, murine
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Gene info
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Identity
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Gene
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Long gene name1-acylglycerol-3-phosphate O-acyltransferase 4
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Synonyms gene name
- 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- 1-acylglycerol-3-phosphate O-acyltransferases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameproteasome 20S subunit beta 6
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Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 6
- proteasome subunit beta 6
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-05-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Proteasome
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameAT-hook containing transcription factor 1 pseudogene 1
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Synonyms gene
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Synonyms gene name
- AT hook containing transcription factor 1 pseudogene
- AT hook containing transcription factor 1 pseudogene 1
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Synonyms
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Locus
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Discovery year2005-06-20
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Entrez gene record
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RefSeq identity
Gene info
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Identity
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Gene
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Long gene nameprotein phosphatase, Mg2+/Mn2+ dependent 1D
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Synonyms gene name
- protein phosphatase 1D magnesium-dependent, delta isoform
- protein phosphatase, Mg2+/Mn2+ dependent, 1D
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-10-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Protein phosphatases, Mg2+/Mn2+ dependent
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameinhibitor of growth family, X-linked (pseudogene)
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Synonyms gene
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Synonyms gene name
- inhibitor of growth family, member 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-01-20
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameproteasome subunit alpha 6 pseudogene 1
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Synonyms gene
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Synonyms gene name
- proteasome (prosome, macropain) subunit, alpha type, 6 pseudogene
- proteasome (prosome, macropain) subunit, alpha type, 6 pseudogene 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-02-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameAF4/FMR2 family member 3
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Synonyms gene
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Synonyms gene name
- lymphoid nuclear protein related to AF4
- AF4/FMR2 family, member 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-03-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Super elongation complex
- AF4/FMR2 family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namelysophosphatidic acid receptor 4
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Synonyms gene
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Synonyms gene name
- G protein-coupled receptor 23
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-08-16
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Entrez gene record
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RefSeq identity
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Classification
- Lysophosphatidic acid receptors
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nametranscription factor Dp family member 3
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Synonyms gene name
- transcription factor Dp family, member 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-07-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Transcription factor Dp family
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameprotein phosphatase 1 regulatory inhibitor subunit 1C
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Synonyms gene name
- protein phosphatase 1, regulatory (inhibitor) subunit 1C
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Protein phosphatase 1 regulatory subunits
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data