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PYR 41 for cell activation

PYR 41 for cell activation is available 2 times from Biovision labs

1925-5 | PYR-41 for cell activation size: 5 mg | 167.92 USD

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1925-25 | PYR-41 for cell activation size: 25 mg | 494.69 USD

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Other name 4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Supplied with N/A
Description Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
Category Biochemicals
Molecular formula C₁₇H₁₃N₃O₇
Is it cell-permeable? Yes
Molecular weight 371.3
Storage condition -20°C
Shipping condition gel pack
Purification ≥98% by TLC
Peptide sequence N/A
Is this a salt? No
CAS number 418805-02-4
Storage instructions Protect from light and air
Maximum time for storage 36 months
Physical appearance Brown solid
Reconstitute instructions DMSO (~25 mg/ml)
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetPYR-41 for activation
Short name PYR-41 for activation
Technique activation
Alternative name PYR-41 to measure cellular activation
Tissue cell
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