-
Alternative_name
2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide; Taselisib
-
Description
GDC-0032 is a potent, and selective inhibitor of Class I PI3-K α, δ, and γ isoforms, with 30-fold less inhibition of the PI3K β isoform relative to the PI3K α isoform. This next generation PI3-K inhibitor displays increased anti-tumor activity against PIK3CA mutant (MT) cell lines.
-
CAS Number
1282512-48-4
-
Structure Available
Yes
-
Salt Form
No
-
Molecular Formula
C₂₄H₂₈N₈O₂
-
Molecular Weight
460.53
-
Cell Permeable
Yes
-
Purity
≥98% by HPLC
-
Solubilities
DMSO (>10 mg/ml)
-
Handling
Protect from air and light
-
Tag Line
A potent, and selective inhibitor of Class I PI3-K α, δ, and γ isoforms, with 30-fold less inhibition of the PI3K β isoform relative to the PI3K α isoform.
-
Storage Condition
-20°C
-
Shipping Condition
gel pack
-
Shelf Life
36 months
-
PubChem CID
51001932
-
-
SMILES
CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C
-
InChi
InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
-
InChi Key
BEUQXVWXFDOSAQ-UHFFFAOYSA-N
-
-
MSDS Available
Yes
