MK-4827 (Tosylate)

Alternative_name

(3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine Tosylate; MK-4827 Tosylate; Niraparib tosylate
Description

MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumor models with loss of BRCA and PTEN function.
CAS Number

1038915-73-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₉H₂₀N₄O •C₇H₈O₃S
Molecular Weight

492.6
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~25 mg/ml)
Handling

Protect from air and light
Tag Line

A selective PARP-1 and PARP-2 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

78357761
PubChem CID Link
SMILES

CC1=CC=C(C=C1)S(=O)(=O)O.C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
InChi

InChI=1S/C19H20N4O.C7H8O3S/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;1-6-2-4-7(5-3-6)11(8,9)10/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);2-5H,1H3,(H,8,9,10)/t14-;/m1./s1
InChi Key

LCPFHXWLJMNKNC-PFEQFJNWSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:7530
Gene

MVK
Long gene name

mevalonate kinase
Synonyms gene name
- mevalonate kinase (mevalonic aciduria)
Synonyms
- LRBP
- MK
Synonyms name
- LH receptor mRNA-binding protein
- mevalonic aciduria
GenBank acession
- M88468
Locus

12q24.11
Discovery year

1992-10-06
Entrez gene record

4598
Pubmed identfication
- 1377680
RefSeq identity
- NM_000431
VEGA ID

OTTHUMG00000169256
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_156

Identity

HGNC:6888
Gene

MAPKAPK3
Long gene name

MAPK activated protein kinase 3
Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 3
Synonyms
- 3pK
- MAPKAP3
- 3PK
- MK-3
- MK3
GenBank acession
- U43784
Locus

3p21.2
Discovery year

1999-03-26
Entrez gene record

7867
Pubmed identfication
- 8626550
- 8622688
RefSeq identity
- NM_004635
Classification
- MAPK activated protein kinases
VEGA ID

OTTHUMG00000156850

Identity

HGNC:11529
Gene

EPCAM
Long gene name

epithelial cell adhesion molecule
Synonyms gene
- M4S1
- MIC18
- TACSTD1
Synonyms gene name
- antigen identified by monoclonal antibody AUA1
- tumor-associated calcium signal transducer 1
Synonyms
- Ly74
- TROP1
- GA733-2
- EGP34
- EGP40
- EGP-2
- KSA
- CD326
- Ep-CAM
- HEA125
- KS1/4
- MK-1
- MH99
- MOC31
- MOC-31
- 323/A3
- 17-1A
- TACST-1
- CO-17A
- ESA
- BerEp4
- Ber-Ep4
Synonyms name
- trophoblast cell surface antigen 1
GenBank acession
- M33011
Locus

2p21
Discovery year

1995-10-02
Entrez gene record

4072
Pubmed identfication
- 8382772
- 11306819
Classification
- MicroRNA protein coding host genes
- CD molecules
VEGA ID

OTTHUMG00000128853
Locus Specific Databases
- Global Variome shared LOVD
- LRG_215