M-CSF Recombinant Protein

  • Catalog number
    40-620
  • Price
    Please ask
  • Size
    0.01 mg
  • About recombinant protein
    M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits.
  • Other name of the recombinant
    op, Csfm, MCSF, C87615, Macrophage colony-stimulating factor 1, CSF-1
  • Recombinant in
    E. coli
  • His tag on the recombinant protein
    no His tag
  • SEQUENCE
    MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP
  • Activity
    Determined by its ability to stimulate the proliferation of murine M-NFS-60 cells. The expected ED50 is = 1.0 ng/mL, corresponding to a specific activity of =1 x 106 units/mg.
  • Keep at
    The lyophilized M-CSF recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted M-CSF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing M-CSF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • Rec PROTEIN GI
    166064046
  • Accession nr
    NP_001107001.1
  • Pureity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
  • About
    This product is for research use only.
  • Protein s origin
    Murine
  • Vial
    Lyophilized
  • NCBI ID
    12977
  • Gene name
    colony stimulating factor 1 (macrophage)
  • Source
    Mus musculus
  • Uniprot
    P07141
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    M-CSF   Protein  
  • Gene symbol
    Csf1
  • Short name
    M-CSF Recombinant Protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative name
    M-CSF Rec. Protein
  • Alternative technique
    rec
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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