MUC18 /CD146 / MCAM (Melanoma Cell Adhesion Molecule) Mouse Monoclonal Antibody

• Catalog number
  MBS439099
• Price
  Please ask
• Size
  0.02 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [MUC18 /CD146 / MCAM (Melanoma Cell Adhesion Molecule)]
• Products_name_syn
  [Cell Surface Glycoprotein MUC18, Cell Surface Glycoprotein P1H12, Gicerin, Melanoma Adhesion Molecule (MCAM), Melanoma Associated Glycoprotein MUC18, Melanoma Cell Adhesion Molecule, Melanoma-associated Antigen A32, Mel-CAM, S-endo 1 Endothelial-associated Antigen, Sendo1]
• Other_names
  [cell surface glycoprotein MUC18; Cell surface glycoprotein MUC18; cell surface glycoprotein MUC18; melanoma cell adhesion molecule; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146]
• Products_gene_name
  [MCAM]
• Other_gene_names
  [MCAM; MCAM; CD146; MUC18; MUC18]
• Clonality
  Monoclonal
• Clone
  [C146/634]
• Reactivity
  Human
• Specificity
  The human CD146 gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
• Description
  cell adhesion molecules play a role in cell growth and activation and are often identified by WB or ELISA as in the MUC18 /CD146 / MCAM (Melanoma Adhesion Molecule) Mouse Monoclonal Antibody. For cells, cell lines and tissues in culture till half confluency. Whole adhesion and interacting molecules are  present in lysates used as reference for ELISA quantification of these molecules and their subunits.
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  MUC18   CD146   MCAM   Melanoma   Adhesion   Molecule   Monoclonal  
• Gene symbol
  MCAM
• Short name
  MUC18 /CD146 / MCAM (Melanoma Adhesion Molecule) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG1, kappa
• Species
  Mouse, Mouses
• Alternative name
  MUC18 /CD146 / melanoma cell adhesion molecule (Melanoma cellular Adhesion Molecule) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine
• Alternative to gene target
  melanoma cell adhesion molecule, CD146 and MUC18, MCAM and IDBG-74428 and ENSG00000076706 and 102465453,4162, protein binding, nuclei, Mcam and IDBG-155835 and ENSMUSG00000032135 and 84004, MCAM and IDBG-631776 and ENSBTAG00000006835 and 281301
• Tissue
  cell

Gene info

• Identity
  HGNC:6934
• Gene
  MCAM
• Long gene name
  melanoma cell adhesion molecule
• Synonyms
  • MUC18
  • CD146
  • MelCAM
  • METCAM
  • HEMCAM
• Synonyms name
  • Gicerin
• GenBank acession
  • X68264
• Locus
  11q23.3
• Discovery year
  1995-12-18
• Entrez gene record
  4162
• Pubmed identfication
  • 2602381
  • 10702685
  • 19229070
• Classification
  • Ig-like cell adhesion molecule family
  • C2-set domain containing
  • V-set domain containing
  • MicroRNA protein coding host genes
  • CD molecules
• VEGA ID
  OTTHUMG00000166197

MeSH Data

• Name
  Mammary Neoplasms, Experimental
• Concept
  Scope note: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
• Tree numbers
  • C04.588.531.500
  • C04.619.590
  • E05.598.500.496.843
• Qualifiers
  diagnosis, parasitology, immunology, microbiology, diagnostic imaging, physiopathology, secondary, enzymology, etiology, mortality, epidemiology, blood, cerebrospinal fluid, chemically induced, congenital, diet therapy, drug therapy, therapy, chemistry, psychology, urine, virology, history, blood supply, classification, economics, embryology, genetics, nursing, radiotherapy, prevention & control, pathology, ultrastructure, metabolism, complications, surgery

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