ALK inhibitor 1

Alternative_Names

NA
CAS

761436-81-1
MWt

562.48
Formula

C23H28BrN7O3S
Solubility

10 mM in DMSO
Clinical_Information

No Development Reported
Pathway

Protein Tyrosine Kinase/RTK
Target

ALK
Datasheet
SDS
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

ALK inhibitor
Gene symbol

ALK, ENPP7, TGFBR1, BMPR2
Short name

ALK inhibitor 1
Alternative name

anaplastic lymphoma receptor tyrosine kinase suppressor 1
Alternative to gene target

anaplastic lymphoma receptor tyrosine kinase, CD246 and NBLST3, ALK and IDBG-42084 and ENSG00000171094 and 238, transferase activity, Plasma membranes, Alk and IDBG-197259 and ENSMUSG00000055471 and 11682, ALK and IDBG-636042 and ENSBTAG00000007379 and 536642

Identity

HGNC:427
Gene

ALK
Long gene name

ALK receptor tyrosine kinase
Synonyms gene name
- anaplastic lymphoma kinase (Ki-1)
- anaplastic lymphoma receptor tyrosine kinase
Synonyms
- CD246
- ALK1
GenBank acession
- D45915
Locus

2p23.2-p23.1
Discovery year

1993-08-24
Entrez gene record

238
Pubmed identfication
- 8122112
RefSeq identity
- NM_004304
Classification
- Receptor tyrosine kinases
- CD molecules
VEGA ID

OTTHUMG00000152034
Locus Specific Databases
- LRG_488

Identity

HGNC:11772
Gene

TGFBR1
Long gene name

transforming growth factor beta receptor 1
Synonyms gene
- MSSE
- ESS1
Synonyms gene name
- multiple self-healing squamous epithelioma
- transforming growth factor beta receptor I
Synonyms
- ALK-5
- ACVRLK4
- ALK5
- TBRI
- TBR-i
Synonyms name
- activin A receptor type II-like kinase, 53kDa
Locus

9q22.33
Discovery year

1993-09-30
Entrez gene record

7046
Pubmed identfication
- 1319842
- 8530052
- 21358634
Classification
- Type 1 receptor serine/threonine kinases
VEGA ID

OTTHUMG00000020353
Locus Specific Databases
- LOVD - Center for Medical Genetics, Ghent, Belgium

Identity

HGNC:1078
Gene

BMPR2
Long gene name

bone morphogenetic protein receptor type 2
Synonyms gene
- PPH1
Synonyms gene name
- primary pulmonary hypertension 1
- bone morphogenetic protein receptor, type II (serine/threonine kinase)
- bone morphogenetic protein receptor type II
Synonyms
- BRK-3
- T-ALK
- BMPR3
- BMPR-II
GenBank acession
- Z48923
Locus

2q33.1-q33.2
Discovery year

1997-03-19
Entrez gene record

659
Pubmed identfication
- 7791754
RefSeq identity
- NM_001204
Classification
- Type 2 receptor serine/threonine kinases
VEGA ID

OTTHUMG00000133617
Locus Specific Databases
- LRG_712