Bml-210, HDAC inhibitor
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Catalog numberSIH-348-5MG
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PricePlease ask
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Size5 mg
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Stock availabilitIn StockIn Stock
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CAS number537034-17-6
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DescriptionHDAC inhibitor
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Molecular weight339,4 g/mol
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Primary research fieldsCell Signaling, Epigenetics, Cancer
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Other nameN1-(2-aminophenyl)-N8-phenyloctanediamide
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC20H25N3O2
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OriginSynthetic
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Purity pourcentage>98% (TLC), NMR conforms
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Soluble inSoluble in 25 mg/ml DMSO or 10 mg/ml Ethanol
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Physical appearanceTan Solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H413 – May cause long lasting harmful effects to aquatic life.
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PubChem number9543540
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Scientific contextA novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 µM (HeLa nuclear extract). Induces growth inhibition, proapoptotic and differentiation effects on human leukemia cell lines.
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Bibliography1. Savickiene J., et al. (2006) Eur. J. Pharmacol. 549: 9. 2. Herman D., et al. (2006) Nature Chem. Biol. 10: 551.
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Release date1-Aug-2012
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of BML-210 (SIH-348), a HDAC inhibitor. CAS #: 537034-17-6. Molecular Formula: C20H25N3O2 . Molecular Weight: 339.4 g/mol. Chemical structure of BML-210, a HDAC inhibitor (SIH-348). CAS # 537034-17-6. Molecular Formula: C20H25N3O2 .
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.005
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolHDAC4, HDAC9
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Short nameBml-210, HDAC inhibitor
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Alternative nameBml-210, HDAC suppressor
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Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 4
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Synonyms gene
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Synonyms gene name
- brachydactyly-mental retardation syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namehistone deacetylase 9
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-09-06
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Entrez gene record
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Pubmed identfication
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Classification
- Histone deacetylases, class IIA
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VEGA ID