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AGO2 Polyclonal Antibody

AGO2 Polyclonal Antibody is available 2 times from Bioma labs

CAC07145 | AGO2 Polyclonal Antibody size: 50 μg | 278.79 USD

Catalog number CAC07145
Supplier bioma
Price 278.79 USD
Size 50 μg
1. Gene info
Identity3263
GeneAGO2
Synonyms gene
Synonyms gene name
  • eukaryotic translation initiation factor 2C, 2
  • cancer susceptibility candidate 7 (non-protein coding)
Synonyms name
GenBank acession
Locus8q24.3
Discovery year2000-01-14
Pubmed identfication
RefSeq identity
Havana BLAST/BLATOTTHUMG00000164232
2. Gene info
Identity48905
GeneCASC7
Synonyms gene
Synonyms gene name
  • eukaryotic translation initiation factor 2C, 2
  • cancer susceptibility candidate 7 (non-protein coding)
Synonyms name
GenBank acession
Locus8q24.3
Discovery year2000-01-14
Pubmed identfication
RefSeq identity
Havana BLAST/BLATOTTHUMG00000164232
MeSH Data
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200

CAC07145 | AGO2 Polyclonal Antibody size: 100 μg | 456.30 USD

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Other name Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,PAZ Piwi domain protein,Protein slicer,EIF2C2,AGO2
Clonality Polyclonal
Purity Caprylic Acid Ammonium Sulfate Precipitation Purified
Estimated production time 3-7 business days
Raised in Rabbit
NCBI number Please refer to NCBI
Gene number Please refer to GenBank
Immunogen Recombinant human Protein argonaute-2 protein (517-818AA)
Protein number Q9UKV8
Notes For research use only. Not for diagnostic procedures.
Use before 1 year
Storage recommendation Aliquot and store at -20°C. Minimize freezing and thawing.
Shipping requirements Blue ice
Verified reactivity Human, Mouse
Supplementary information Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The minimal RISC appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
Verified applications ELISA,WB,IHC,ChIP
Properties If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
French translation anticorps
Gene targetAGO2
Short name AGO2 Polyclonal Antibody
Technique Polyclonal, Antibody
Alternative name AGO2 polyclonal (Antibody to)
Alternative technique polyclonals
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