Bml 259, CDK5, p25 kinase inhibitor

  • Catalog number
    SIH-435-5MG
  • Price
    Please ask
  • Size
    5 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    267654-00-2
  • Description
    CDK5, p25 kinase inhibitor
  • Molecular weight
    260,4 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    N-(5-Isopropylthiazol-2-yl)phenylacetamide
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C14H16N2OS
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (TLC)
  • Soluble in
    Soluble in DMSO (30 mg/ml), dimethyl formamide (30 mg/ml) or 100% ethanol (0.25 mg/ml)
  • Physical appearance
    White solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
  • PubChem number
    16760027
  • Scientific context
    Bml 259 is a potent inhibitor of Cdk5/p25. It also inhibits Cdk2/cyclin E.
  • Bibliography
    1. Kaźmierczak A., Czapski G.A., Adamczyk A., Gajkowska B., & Strosznajder J.B. (2011) Neurochem. Int. 58(2): 206–214.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of BML 259 (SIH-435), a CDK5/p25 kinase inhibitor. CAS #: 267654-00-2. Molecular Formula: C14H16N2OS. Molecular Weight: 260.4 g/mol. Chemical structure of BML 259, a CDK5/p25 kinase inhibitor (SIH-435). CAS # 267654-00-2. Molecular Formula: C14H16N2OS.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.005
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
    Bml   259   CDK5   p25   kinase   inhibitor  
  • Gene symbol
    CDK5
  • Short name
    Bml 259, CDK5, p25 kinase inhibitor
  • Alternative name
    Bml 259, cyclin-dependent kinase 5, p25 phosphorylation catalyst suppressor
  • Alternative to gene target
    cyclin-dependent kinase 5, PSSALRE, CDK5 and IDBG-48977 and ENSG00000164885 and 1020, transferase activity, nuclei, Cdk5 and IDBG-141112 and ENSMUSG00000028969 and 12568, CDK5 and IDBG-637527 and ENSBTAG00000007766 and 281066
Gene info
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