insln-like Growth Factor-I, Somatamedin C, IGF-IA
insln-like Growth Factor-I, Somatamedin C, IGF-IA, Mechano growth factor
Highly potent form of endocrine hormone IGF-1
NCBI Gene ID #.
NCBI Gene Symbol
Activity (Specifications/test method)
The ED₅₀ as determined by a cell proliferation assay using NIH3T3 cells is typically 1-6 ng/ml.
Physical form description
Lyophilized with no additives
Reconstitute in dH₂O or 10 mM AcOH to 1.0 mg/ml. This solution can then be diluted into other buffered solutions or stored at 4°C for 1 week or –20°C for future use.
Centrifuge the vial prior to opening.
For Research Use Only! Not to be used in humans
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
Recombinants or rec. proteins
R³ IGF-1, recombinant
R³ IGF-1, H. sapiens recombinant