IGF-BP3 Antibody

• Catalog number
  5720-30T
• Price
  Please ask
• Size
  30 µg

• Antibody Target
  IGF-BP3
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  E. coli expressed human IGF-BP3 (Cat.# 4720-25)
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  30 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal.
• Purification
  Affinity purified
• Application
  Western blot
• Application And Usages
  Western blotting (2-6 µg/ml). However, the optimal conditions should be determined individually. Recombinant human IGFBP-3 (Cat.# 4720-25) can be used as a positive control. Other applications have not been determined.
• Description
  Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Additional description
  IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
• French translation
  anticorps

• Gene target
  BP3  
• Gene symbol
  EIF4EBP3, ANKHD1-EIF4EBP3, HS1BP3
• Short name
  IGF-BP3 Antibody
• Technique
  Antibody, IGF, antibodies against human proteins, antibodies for, igfs
• Isotype
  Rabbit IgG
• Alternative name
  IGF-BP3 (antibody to-)
• Alternative technique
  antibodies, igfs

Gene info

• Identity
  HGNC:3290
• Gene
  EIF4EBP3
• Long gene name
  eukaryotic translation initiation factor 4E binding protein 3
• Synonyms
  • 4E-BP3
• GenBank acession
  • AF038869
• Locus
  5q31.3
• Discovery year
  1998-11-18
• Entrez gene record
  8637
• Pubmed identfication
  • 9593750
• RefSeq identity
  • NM_003732
• VEGA ID
  OTTHUMG00000129498

Gene info

• Identity
  HGNC:33530
• Gene
  ANKHD1-EIF4EBP3
• Long gene name
  ANKHD1-EIF4EBP3 readthrough
• Synonyms
  • MASK-BP3
• GenBank acession
  • AF521883
• Locus
  5q31.3
• Discovery year
  2007-07-31
• Entrez gene record
  404734
• Pubmed identfication
  • 16297570
  • 14557257
• RefSeq identity
  • NM_020690
• VEGA ID
  OTTHUMG00000166212

Gene info

• Identity
  HGNC:24979
• Gene
  HS1BP3
• Long gene name
  HCLS1 binding protein 3
• Synonyms
  • HS1-BP3
  • FLJ14249
• Locus
  2p24.1
• Discovery year
  2006-08-15
• Entrez gene record
  64342
• Pubmed identfication
  • 10590261
  • 15699368
• RefSeq identity
  • NM_022460
• VEGA ID
  OTTHUMG00000122099

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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