BMP-11, human recombinant

• Catalog number
  4576-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  bone morphogenetic protein 11, BMP11, BMP 11, Growth/Differentiation Factor-11, GDF-11, GDF11, GDF 11
• Alternative_names
  bone morphogenetic protein 11, BMP11, BMP 11, Growth/Differentiation Factor-11, GDF-11, GDF11, GDF 11
• Description
  A protein that controls anterior-posterior patterning by regulating the expression of Hox genes
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Purity
  ≥98%
• Biological activity
  The protein is biologically active as determined by its ability to induce alkaline phosphatase production by C2C12 cells. The ED₅₀ is in the range of 0.4-4 µg/ml.
• Results
  0.4-4 µg/ml
• Molecular Weight
  32.6 kDa
• Storage Temp
  -20°C
• Shipping
  Blue ice
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized from 10 mM Sodium Citrate, pH 3.5.
• Reconstitution Instructions
  Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 ug BSA per 1 ug of protein). This solution can then be diluted into other aqueous buffers.
• Background Information
  BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Recombinant human BMP-11 is N-terminus His-tagged protein with a molecular weight of 32.6 kDa (for homodimeric) and 16.2 (for monomeric) consisting of 136 amino acid polypeptide chains.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  BMP-11  
• Gene symbol
  GDF11, PIRC52, PIRC51, IGKV1OR2-11, GDF10, PIRC50, SNORD115-11, SNORD114-11
• Short name
  BMP-11, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  BMP-11, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:4216
• Gene
  GDF11
• Long gene name
  growth differentiation factor 11
• Synonyms
  • BMP-11
  • BMP11
• GenBank acession
  • AF100907
• Locus
  12q13.2
• Discovery year
  1999-12-02
• Entrez gene record
  10220
• Pubmed identfication
  • 15988002
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000170188

Gene info

• Identity
  HGNC:37556
• Gene
  PIRC52
• Long gene name
  piwi-interacting RNA cluster 52
• Locus
  11
• Discovery year
  2009-11-05
• Entrez gene record
  100313791
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37555
• Gene
  PIRC51
• Long gene name
  piwi-interacting RNA cluster 51
• Locus
  11
• Discovery year
  2009-11-05
• Entrez gene record
  100313860
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:5768
• Gene
  IGKV1OR2-11
• Long gene name
  immunoglobulin kappa variable 1/OR2-11 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR2-11
  • immunoglobulin kappa variable 1/OR2-11 pseudogene
• Synonyms
  • IGKV1/OR2-11
• GenBank acession
  • X51885
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28863
• Pubmed identfication
  • 2111145
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000184518

Gene info

• Identity
  HGNC:4215
• Gene
  GDF10
• Long gene name
  growth differentiation factor 10
• Synonyms
  • BMP-3b
• GenBank acession
  • L42113
• Locus
  10q11.22
• Discovery year
  1997-09-12
• Entrez gene record
  2662
• Pubmed identfication
  • 8679252
• RefSeq identity
  • NM_004962
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000188319

Gene info

• Identity
  HGNC:37554
• Gene
  PIRC50
• Long gene name
  piwi-interacting RNA cluster 50
• Locus
  11
• Discovery year
  2009-11-05
• Entrez gene record
  100313814
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33030
• Gene
  SNORD115-11
• Long gene name
  small nucleolar RNA, C/D box 115-11
• Synonyms
  • HBII-52-11
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033448
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003303.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:32999
• Gene
  SNORD114-11
• Long gene name
  small nucleolar RNA, C/D box 114-11
• Synonyms
  • 14q(II-11)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767589
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003204.1
• Classification
  • Small nucleolar RNAs, C/D box

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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