OX40/TNFRSF4

• Catalog number
  E21-K60
• Price
  Please ask
• Size
  10ug

• Shipping_Temperature
  Ambient
• Product_State
  Lyophilized
• Formulation_Description
  Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• Storage
  Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Reconstitution
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Background
  OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
• Alternative Names
  Tumor necrosis factor receptor superfamily member 4;TNFRSF4;OX40;CD134;Txgp1
• Expression system
  Human Cells

• Gene target
  OX40/TNFRSF4  
• Gene symbol
  TNFRSF4
• Short name
  OX40/TNFRSF4
• Species
  Human
• Alternative name
  OX40/tumor necrosis factor receptor superfamily, member 4
• Alternative to gene target
  tumor necrosis factor receptor superfamily, member 4, ACT35 and CD134 and IMD16 and OX40 and TXGP1L, TNFRSF4 and IDBG-84605 and ENSG00000186827 and 7293, protein binding, Cell surfaces, Tnfrsf4 and IDBG-208242 and ENSMUSG00000029075 and 22163, TNFRSF4 and IDBG-635323 and ENSBTAG00000015635 and 528782

Gene info

• Identity
  HGNC:11918
• Gene
  TNFRSF4
• Long gene name
  TNF receptor superfamily member 4
• Synonyms gene
  • TXGP1L
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 4
• Synonyms
  • ACT35
  • OX40
  • CD134
• GenBank acession
  • X75962
• Locus
  1p36.33
• Discovery year
  1994-12-15
• Entrez gene record
  7293
• Pubmed identfication
  • 7510240
  • 2828930
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000001415
• Locus Specific Databases
  • LRG_1319

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