Cyclosporine, Immunosuppressant

• Catalog number
  SIH-201-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  59865-13-3
• Description
  Immunosuppressant
• Molecular weight
  1202,63 g/mol
• Primary research fields
  Cancer, Apoptosis
• Other name
  (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C62H111N11O12
• Origin
  Synthetic
• Purity pourcentage
  >99%
• Soluble in
  Soluble to 100 mM in DMSO, 50 mM in ethanol
• Physical appearance
  White Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R45 - May cause cancer R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302-H350-H360 Precautionary Phrases: P201-P308 + P313
• PubChem number
  5284373
• Scientific context
  Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
• Bibliography
  1. Heitman J., et al. (1992) New Biol. 4:448. 2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.
• Release date
  8-Apr-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Cyclosporine (SIH-201), a Inhibits mitochondrial permeability pore opening. CAS #: 59865-13-3. Molecular Formula: C62H111N11O12 . Molecular Weight: 1202.63 g/mol. Chemical structure of Cyclosporine, a Inhibits mitochondrial permeability pore opening (SIH-201). CAS # 59865-13-3. Molecular Formula: C62H111N11O12 .
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products

• Gene target
  Cyclosporine   Immunosuppressant  
• Short name
  Cyclosporine, Immunosuppressant
• Alternative name
  Cyclosporine, Immunosuppressant

Similar products