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Gene info
ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.
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Gene names
AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, C1orf215, LAP18, OP18, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, kinase ATM
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Antibodie s label
unlabelled serum
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Purity
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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Ab raised in
Rabbit
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Type
Polyclonal
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Spicific to
This antibody detects endogenous level of total ATM protein.
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Antigen
ATM (Ab-1981) antibody was made against a peptide sequence around aa.1979~1983 (E-G-S-Q-S) derived from Human ATM.
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Immuno application
Western Blot, immuno fluorescence
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Antibody advice
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
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Suspention pH azide
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Keep at
Store antibody at -20 grades C for up to one year.
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Works with
Human, Mouse
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Omim nr
71902540
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Ncbi nr
NP_000042.3
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KDa
350 kDa
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
472
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GENE symbol
ATM
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Antigene name
ataxia telangiectasia mutated
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Source
Homo sapiens
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Protein nr
Q13315
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
ATM
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Short name
anti-ATM (Ab 1981) Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toATM (Antibody 1981) (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
ataxia telangiectasia mutated, AT1 and ATA and ATC and ATD and ATDC and ATE and TEL1 and TELO1, ATM and IDBG-70193 and ENSG00000149311 and 472, transferase activity, nuclei, Atm and IDBG-165511 and ENSMUSG00000034218 and 11920, ATM and IDBG-629882 and ENSBTAG00000003111 and 526824
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