Synonyms
Acrogranin, Paragranulin, Granulin-2
Alternative_names
Acrogranin, Paragranulin, Granulin-2
Purity by SDS-PAGE
≥90%
Purity
≥90%
Biological activity
Measured by chemotaxis using THP-1 cells.
Molecular Weight
88.0 kDa
Concentration
0.5 mg/ml
Appearance
Liquid
Physical form description
Sterile filtered clear solution in PBS
Background Information
Progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6.0 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 amino acids and having a molecular mass of 88.0 kDa. The Progranulin is purified by standard chromatographic techniques.
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants
Gene targetCellExp™
Progranulin
Short name
CellExp™ Progranulin, Recombinant
Technique
Recombinant
Alternative name
H. sapiens CellExp™ Progranulin, H. sapiens recombinant
