UNC5D/UNC5H4 Antibody, ALEXA FLUOR 488
-
Catalog number
bs-11494R-A488
-
Price
Please ask
-
Size
100ul
-
-
Long name
UNC5D/UNC5H4 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
-
Also known as
Anti-UNC5D/UNC5H4 PAb ALEXA FLUOR 488
-
Category
Conjugated Primary Antibodies
-
Conjugated with
ALEXA FLUOR® 488
-
Host Organism
Rabbit (Oryctolagus cuniculus)
-
Target Antigen
UNC5D/UNC5H4
-
Specificity
This is a highly specific antibody against UNC5D/UNC5H4.
-
Modification
Unmodified
-
Modification Site
None
-
Clonality
Polyclonal
-
Clone
Polyclonal antibody
-
Concentration
1ug per 1ul
-
Subcellular location
Extracellular
-
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UNC5H4
-
Tested applications
IF(IHC-P)
-
Recommended dilutions
IF(IHC-P)(1:50-200)
-
Crossreactivity
Human, Mouse, Rat
-
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the antigen
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.
-
Purification
Purified by Protein A.
-
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
-
Excitation emission
499nm/519nm
-
Synonyms
Netrin receptor UNC5D; Netrin receptor Unc5h4; Protein unc 5 homolog D; Unc 5 homolog 4; Unc 5 homolog D C. elegans; Unc 5 homolog D; UNC 5D; Unc5h4; FLJ16019; KIAA1777.
-
Properties
For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-UNC5D/UNC5H4 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
Conjugation
Alexa Fluor
-
French translation
anticorps
-
Gene target
-
Gene symbol
UNC5D
-
Short name
Anti-UNC5D/UNC5H4
-
Technique
Antibody, antibodies against human proteins, antibodies for
-
Isotype
Immunoglobulin G (IgG)
-
Label
ALEXA FLUOR 488
-
Alternative name
UNC5D/UNC5H4 Polyclonal Antibody, ALEXA FLUOR 488
-
Alternative technique
antibodies
-
Alternative to gene target
unc-5 homolog D (C. elegans), UNC5D and IDBG-16693 and ENSG00000156687 and 137970, protein binding, Cell surfaces, Unc5d and IDBG-146351 and ENSMUSG00000063626 and 210801, UNC5D and IDBG-628993 and ENSBTAG00000010241 and 520004
-
Gene info
-
Identity
-
Gene
-
Long gene name
unc-5 netrin receptor D
-
Synonyms gene name
- unc-5 homolog D (C. elegans)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
2002-05-13
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Ig-like cell adhesion molecule family
- I-set domain containing
-
VEGA ID
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products