Anti-HUMAN PARKIN (pSer378)

  • Catalog number
    MBS222786
  • Price
    Please ask
  • Size
    100ul
  • Alternative name1
    Anti-RABBIT ANTI HUMAN PARKIN (pSer378)
  • Alternative name2
    RABBIT ANTI HUMAN PARKIN (pSer378)
  • Alternative name3
    Lapin ANTI Homo sapiens PARKIN (pSer378)
  • Alternative name4
    PARKIN
  • Alternative name5
    N/A
  • Other names
    E3 ubiquitin-protein ligase parkin isoform 1; E3 ubiquitin-protein ligase parkin; E3 ubiquitin-protein ligase parkin; parkinson juvenile disease protein 2; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson protein 2, E3 ubiquitin protein ligase (parkin); Parkinson juvenile disease protein 2
  • Gene name
    N/A
  • Gene name synonims
    N/A
  • Other gene names
    PARK2; PARK2; PDJ; PRKN; AR-JP; LPRS2; PRKN; Parkinson disease protein 2
  • Category
    Antibodies
  • Clonality
    Polyclonal
  • Immunoglobulin isotype
    Polyclonal IgG
  • Clone
    Polyclonal antibody
  • Host organism
    Rabbit
  • Species reactivity
    Human
  • Specificity and cross reactivity
    PARKIN This item specifically recognises the 52kDa parkin protein, when phosphorylated at Ser378. _x000D__x000D_Parkin is an E3 ubiquitin ligase highly expressed in the brain, which functions in the ubiquitin-proteasome system, together with the E2 ubiquitin conjugating co-enzyme UbcH7. Mutations in the parkin gene are associated with the hereditary neurodegenerative disorder known as autosomal recessive early onset Parkinson disease 2 (PARK2)/autosomal recessive juvenile Parkinson disease (PDJ), characterized by progressive dopaminergic neural cell death. Studies have identified the presence of at least five phosphorylation sites in parkin including Ser378, shown to be phosphorylated by Casein kinase-1 (CK-1), and suggest that phosphorylation of parkin may act to regulate its ubiquitin ligase activity.
  • Purification method
    N/A
  • Form Appearance
    Purified (Purified IgG - liquid)
  • Concentration
    N/A
  • Storage and shipping
    Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of dispatch.
  • Tested for
    Western Blot (WB)
  • Description
    productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
  • Advisory
    In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Additional description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Test
    MBS Polyclonals supplies antibodies that are for research of human proteins.
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Gene target
    PARKIN   pSer378  
  • Gene symbol
    PRKN
  • Short name
    Anti- PARKIN (pSer378)
  • Technique
    anti-Human, anti-, anti, antibody to, antibodies, antibodies against human proteins
  • Species
    Human, Humans
  • Alternative name
    Antibody toHUMAN PARKIN (pSer378)
  • Alternative technique
    antibodies
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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