ABCA4 Antibody

• Catalog number
  R31176
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ABCA4
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the ABCA4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ABCA4 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P78363
• Purity
  Antigen affinity
• Description
  ATP-Binding Cassette, Subfamily A, Member 4, also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. It is a member of the ATP-binding cassette transporter gene sub-family A(ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, Allikmets et al.(1997) mapped the gene to 1p21-p13. Allikmets et al.(1997) localized transcripts exclusively within photoreceptor cells, indicating that ABCA4 mediates the transport of an essential molecule(or ion) either into or out of photoreceptor cells. Molday et al.(2000) showed by immunofluorescence microscopy and Western blot analysis that ABCA4 is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCA4-mediated foveal cone degeneration.
• Immunogen
  An amino acid sequence from the C-terminus of human ATP-Binding Cassette, Subfamily A, Member 4 (TLLVQRHFFLSQWI) was used as the immunogen for this ABCA4 antibody.
• Storage
  After reconstitution, the ABCA4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ABCA4  
• Gene symbol
  ABCA4
• Short name
  Anti-ABCA4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to ABCA4
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:34
• Gene
  ABCA4
• Long gene name
  ATP binding cassette subfamily A member 4
• Synonyms gene
  • STGD1
  • ABCR
  • RP19
  • STGD
• Synonyms gene name
  • ATP-binding cassette transporter, retinal-specific
  • ATP-binding cassette, sub-family A (ABC1), member 4
• Synonyms
  • FFM
  • ARMD2
  • CORD3
• Synonyms name
  • Stargardt disease
• GenBank acession
  • U88667
• Locus
  1p22.1
• Discovery year
  1994-07-14
• Entrez gene record
  24
• Pubmed identfication
  • 9490294
• RefSeq identity
  • NM_000350
• Classification
  • ATP binding cassette subfamily A
• VEGA ID
  OTTHUMG00000010622
• Locus Specific Databases
  • Mutations of the ATP-binding Cassette Transporter Retina

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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