AG 879, NGFR kinase inhibitor
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Catalog number
SIH-429-5MG
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Price
Please ask
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Size
5 mg
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Stock availabilitIn Stock
In Stock
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CAS number
148741-30-4
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Description
NGFR kinase inhibitor
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Molecular weight
316,5 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
Tyrphostin AG 879, α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C18H24N2OS
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Origin
Synthetic
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Purity pourcentage
≥99% (TLC)
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Soluble in
Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml)
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Physical appearance
Yellow solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
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PubChem number
5487525
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Scientific context
AG879 is a selective inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. It also inhibits ErbB2 and VEGFR-2.
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Bibliography
1. He H., et al. (2004) Cancer Biol. Therapy. 3(1): 96–101. 2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of AG 879 (SIH-429), a NGFR kinase inhibitor. CAS #: 148741-30-4. Molecular Formula: C18H24N2OS. Molecular Weight: 316.5 g/mol. Chemical structure of AG 879, a NGFR kinase inhibitor (SIH-429). CAS # 148741-30-4. Molecular Formula: C18H24N2OS.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
NGFR-AS1, NGFR
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Short name
AG 879, NGFR kinase inhibitor
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Alternative name
AG 879, nerve growth factor receptor phosphorylation catalyst suppressor
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Alternative to gene target
nerve growth factor receptor, CD271 and Gp80-LNGFR and p75(NTR) and p75NTR and TNFRSF16, NGFR and IDBG-57653 and ENSG00000064300 and 4804, nerve growth factor binding, nuclei, Ngfr and IDBG-209608 and ENSMUSG00000000120 and 18053, NGFR and IDBG-638806 and ENSBTAG00000020979 and 353110
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Gene info
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Identity
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Gene
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Long gene name
NGFR antisense RNA 1
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Locus
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Discovery year
2021-04-07
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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