Alpha 2 Macroglobulin Antibody
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Catalog number
7015-30T
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Price
Please ask
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Size
30 µg
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Antibody Target
Alpha 2 Macroglobulin
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Target Alternative Name
C3 and PZP-like alpha-2-macroglobulin domain containing protein 5, A2M, CPAMD5, FWP007
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Antibody Type
Polyclonal
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Species Reactivities
Human
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Immunogen Sequence
Human alpha 2 Macroglobulin (Cat # 7296)
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Accession
P01023
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Gene Id
2
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
0.5 mg/ml
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Formulation
30 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin® and 50 % glycerol.
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Purification
Affinity purified rabbit IgG
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Application
Western blot
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Positive Control
Western blot: h serum, recombinant protein
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Application And Usages
Western blot: 1-4 µg
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Description
Alpha 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. It functions as a broad-spectrum protease-binding protein. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells.
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Western Blot Verified
Verified
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Immunocytochemistry Verified
Not Verified
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Immunofluorescence Verified
Not Verified
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Immunoprecipitation Verified
Not Verified
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ELISA Verified
Not Verified
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ChIP Verified
Not Verified
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Dot Blot Verified
Not Verified
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Flow Cytometry Verified
Not Verified
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Additional description
The Alpha 2 Macroglobulin Antibody is a α- or alpha protein sometimes glycoprotein present in blood.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
A2MP1, PZP, A2ML1
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Short name
Alpha 2 Macroglobulin Antibody
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
rabbit IgG
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Alternative name
a 2 Macroglobulin (antibody to-)
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Alternative technique
antibodies
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Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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