THZ1 hydrochloride

• Catalog number
  9544-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide, hydrochloride
• Description
  THZ1 is a potent, cell-permeable, and selective covalent CDK7 inhibitor (IC₅₀ = 3.2 nM) that preferentially diminishes transcription in cancer cells. It displays unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
• CAS Number
  1604810-83-4 (free base)
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₁H₂₉Cl₂N₇O₂
• Molecular Weight
  602.51
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent CDK7 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  73602827
• PubChem CID Link
• SMILES
  O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5.[H]Cl
• InChi
  InChI=1S/C31H28ClN7O2.ClH/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27;/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38);1H/b11-6+;
• InChi Key
  LSAGMHUBJCPLJS-ICSBZGNSSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  THZ1   hydrochloride  
• Short name
  THZ1 hydrochloride
• Alternative name
  THZ1 hydrochloride

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