A potent and selective DOT1L inhibitor. Treatment of leukemic cells with EPZ004777 results in selective killing of those cells bearing the MLL (mixed lineage leukemia) gene translocation, with little effect on non-MLL-translocated cells.
Is it cell-permeable?
≥98% by HPLC
Is this a salt?
Protect from light and air
Maximum time for storage
For cells, cell lines and tissues in culture till half confluency.
EPZ004777 for activation
EPZ004777 to measure cellular activation