BAY 87-2243

• Catalog number
  B1878-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  5-(1-((2-(4-cyclopropylpiperazin-1-yl)pyridin-4-yl)methyl)-5-methyl-1H-pyrazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
• Description
  BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It inhibits HIF-1α and HIF-2α protein accumulation under hypoxic conditions in non-small cell lung cancer (NSCLC) cell line H460 but had no effect on HIF-1α protein levels induced by the hypoxia mimetics desferrioxamine or cobalt chloride. In addition, BAY 87-2243 is also found to act as an inhibitor of mitochondrial function. It can inhibit the oxygen consumption with IC₅₀ value of 10 nM.
• CAS Number
  1227158-85-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₆H₂₆F₃N₇O₂
• Molecular Weight
  525.53
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>7 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A highly potent and selective inhibitor of hypoxia-induced gene activation.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  67377767
• PubChem CID Link
• SMILES
  CC1=CC(=NN1CC2=CC(=NC=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(C=C6)OC(F)(F)F
• InChi
  InChI=1S/C26H26F3N7O2/c1-17-14-22(25-31-24(33-38-25)19-2-6-21(7-3-19)37-26(27,28)29)32-36(17)16-18-8-9-30-23(15-18)35-12-10-34(11-13-35)20-4-5-20/h2-3,6-9,14-15,20H,4-5,10-13,16H2,1H3
• InChi Key
  CDJNNOJINJAXPV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BAY   87-2243  
• Gene symbol
  WDR93, TRAPPC12
• Short name
  BAY 87-2243
• Alternative name
  BAY 87-2243

Gene info

• Identity
  HGNC:26924
• Gene
  WDR93
• Long gene name
  WD repeat domain 93
• Synonyms
  • FAP297
  • C1d-87
  • CFAP297
• Locus
  15q26.1
• Discovery year
  2007-11-19
• Entrez gene record
  56964
• Pubmed identfication
  • 22573824
• RefSeq identity
  • NM_020212
• Classification
  • WD repeat domain containing
  • Cilia and flagella associated
• VEGA ID
  OTTHUMG00000172007

Gene info

• Identity
  HGNC:24284
• Gene
  TRAPPC12
• Long gene name
  trafficking protein particle complex subunit 12
• Synonyms gene
  • TTC15
• Synonyms gene name
  • tetratricopeptide repeat domain 15
  • trafficking protein particle complex 12
• Synonyms
  • CGI-87
  • TTC-15
• GenBank acession
  • BC017475
• Locus
  2p25.3
• Discovery year
  2003-12-22
• Entrez gene record
  51112
• Pubmed identfication
  • 10810093
  • 21525244
  • 20562859
• RefSeq identity
  • NM_016030
• Classification
  • Trafficking protein particle complex subunits
  • Tetratricopeptide repeat domain containing
• VEGA ID
  OTTHUMG00000090328

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