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SIRT2 Inhibitor

SIRT2 Inhibitor is available 5 times from Biovision labs

1857-25 | SIRT2 Inhibitor size: 25 mg | 448.25 USD

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1857-5 | SIRT2 Inhibitor size: 5 mg | 155.82 USD

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K322-100 | SIRT2 Inhibitor Screening Assay Kit (Fluorometric) size: 100 assays | 613.10 USD

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1651-10 | SIRT2 Inhibitor, AGK2 size: 10 mg | 249.53 USD

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2085-5 | SIRT2 Inhibitor, B2 size: 5 mg | 249.53 USD

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Structure Available? Yes
Cell-Permeable? Yes
Handling Protect from air and light
Shelf Life 24 months
MSDS Available Yes
Summary • Detection method- Fluorescence (Ex/Em 395/541 nm) • Species reactivity- Mammalian • Application- • Screening and characterization of Sirtuin inhibitors.
Sample Type N/A
Features & Benefits • Simple procedure • Fast and convenient • The assay is sensitive, reliable, and high-throughput adaptable.
Storage Conditions -20°C
Shipping Conditions gel pack
Shelf life 12 months
Background Sirtuin or Sir2 proteins are a class of proteins that possess either histone deacetylase or mono-ribosyltransferase activity. Sirtuins have been implicated in influencing aging and regulating transcription, apoptosis and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Unlike other known protein deacetylases, which simply hydrolyze acetyl-lysine residues, the sirtuin-mediated deacetylation reaction couples lysine deacetylation to NAD hydrolysis. This hydrolysis yields O-acetyl-ADP-ribose, the deacetylated substrate and nicotinamide, itself an inhibitor of sirtuin activity. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. In BioVision’s Sirtuin inhibitor screening Kit, Sirtuin deacetylates the substrate and then the developer cleaves the deacetylated substrate to release the fluorescent group, which can be detected fluorometrically at Ex/Em = 395/541 nm. In the presence of SIRT inhibitor, the deacetylation will be impeded which prevents the cleavage of the substrate to release the fluorescent group. The kit provides a rapid, simple, sensitive, and reliable test, which is also suitable for high-throughput screening of SIRT2 inhibitors. Inhibitor control (Nicotinamide) is included to compare the efficacy of the test inhibitors.
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