RO8994
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Catalog numberB1830-25
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PricePlease ask
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Size25 mg
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Alternative_name(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide
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DescriptionRO8994 is a highly potent and selective spiroindolinone small-molecule MDM2 inhibitor, with IC₅₀ of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).
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CAS Number1309684-94-3
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Structure AvailableYes
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Molecular FormulaC₃₁H₃₁Cl₂FN₄O₄
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Molecular Weight613.51
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA highly potent and selective small-molecule MDM2 inhibitor,
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Storage Condition-20°C
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Shipping ConditionGel Pack
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Shelf Life36 months
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PubChem CID53238217
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SMILESCC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
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InChiInChI=1S/C31H31Cl2FN4O4/c1-30(2,3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4/h5-13,23-24,26,38H,14H2,1-4H3,(H2,35,39)(H,36,40)(H,37,41)/t23-,24-,26+,31+/m0/s1
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InChi KeyMURAVORBGFDSMA-ISKXDESKSA-N
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MSDS AvailableYes
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Gene target
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Short nameRO8994
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Alternative nameRO8994
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