RO8994

• Catalog number
  B1830-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide
• Description
  RO8994 is a highly potent and selective spiroindolinone small-molecule MDM2 inhibitor, with IC₅₀ of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).
• CAS Number
  1309684-94-3
• Structure Available
  Yes
• Molecular Formula
  C₃₁H₃₁Cl₂FN₄O₄
• Molecular Weight
  613.51
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A highly potent and selective small-molecule MDM2 inhibitor,
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  53238217
• PubChem CID Link
• SMILES
  CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
• InChi
  InChI=1S/C31H31Cl2FN4O4/c1-30(2,3)14-23-31(18-10-9-16(32)13-21(18)37-29(31)41)24(17-6-5-7-19(33)25(17)34)26(38-23)28(40)36-20-11-8-15(27(35)39)12-22(20)42-4/h5-13,23-24,26,38H,14H2,1-4H3,(H2,35,39)(H,36,40)(H,37,41)/t23-,24-,26+,31+/m0/s1
• InChi Key
  MURAVORBGFDSMA-ISKXDESKSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  RO8994  
• Short name
  RO8994
• Alternative name
  RO8994

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