Cyclin D2 Antibody, ALEXA FLUOR 647

• Catalog number
  bs-1148R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  Cyclin D2 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-Cyclin D2 PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Cyclin D2
• Specificity
  This is a highly specific antibody against Cyclin D2.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  150-200/288
• Subcellular location
  Cytoplasm, Nucleus, Membrane bound
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cyclin D2
• Gene ID Number
  894
• Swiss Prot
  P30279
• Tested applications
  IF(IHC-P), IF(ICC)
• Recommended dilutions
  IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  MPPH3; KIAK2; G1/S-specific cyclin-D2; CCND2
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-Cyclin D2 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

• Gene target
  Cyclin  
• Gene symbol
  CCND2, CCND2P1
• Short name
  Anti-Cyclin D2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  Cyclin D2 Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1583
• Gene
  CCND2
• Long gene name
  cyclin D2
• Synonyms name
  • G1/S-specific cyclin D2
• GenBank acession
  • AF518005
• Locus
  12p13.32
• Discovery year
  1991-12-10
• Entrez gene record
  894
• Pubmed identfication
  • 1386335
• RefSeq identity
  • NM_001759
• Classification
  • Cyclins
• VEGA ID
  OTTHUMG00000168123

Gene info

• Identity
  HGNC:1584
• Gene
  CCND2P1
• Long gene name
  cyclin D2 pseudogene 1
• Synonyms gene
  • CCND2P
• Synonyms gene name
  • cyclin D2 pseudogene
• GenBank acession
  • M91003
• Locus
  11q12.3
• Discovery year
  1991-12-10
• Entrez gene record
  895
• Pubmed identfication
  • 1386335
  • 1386336
• RefSeq identity
  • NG_001092
• VEGA ID
  OTTHUMG00000167849

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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