FAAH Inhibitor, PF-622

• Catalog number
  1928-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-Phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide
• Description
  Cell-permeable. A potent and irreversible FAAH (Fatty Acid Amide Hydrolase) inhibitor. Inhibits FAAH in a time-dependent manner by covalently modifying the enzyme's active site serine (IC₅₀ = 33 nM). It is highly selective for FAAH relative to other mammalian serine hydrolases.
• CAS Number
  898235-65-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₂N₄O
• Molecular Weight
  346.43
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~25 mg/ml) or Ethanol (~ 3 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A potent and irreversible FAAH (Fatty Acid Amide Hydrolase) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11515763
• PubChem CID Link
• SMILES
  C1CN(CCN1CC2=NC3=CC=CC=C3C=C2)C(=O)NC4=CC=CC=C4
• InChi
  InChI=1S/C21H22N4O/c26-21(23-18-7-2-1-3-8-18)25-14-12-24(13-15-25)16-19-11-10-17-6-4-5-9-20(17)22-19/h1-11H,12-16H2,(H,23,26)
• InChi Key
  SNTCRRMCALVGNL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  FAAH   Inhibitor   PF-622  
• Gene symbol
  FAAH, FAAHP1, MIR622, FA2H, FAAH2
• Short name
  FAAH Inhibitor, PF-622
• Alternative name
  FAAH suppressor, PF-622

Gene info

• Identity
  HGNC:3553
• Gene
  FAAH
• Long gene name
  fatty acid amide hydrolase
• Synonyms
  • FAAH-1
• GenBank acession
  • U82535
• Locus
  1p33
• Discovery year
  1998-01-20
• Entrez gene record
  2166
• Pubmed identfication
  • 9122178
• RefSeq identity
  • NM_001441
• VEGA ID
  OTTHUMG00000007811

Gene info

• Identity
  HGNC:50679
• Gene
  FAAHP1
• Long gene name
  fatty acid amide hydrolase pseudogene 1
• Synonyms gene
  • LINC00505
• Synonyms gene name
  • long intergenic non-protein coding RNA 505
• Synonyms
  • FAAH-OUT
• Locus
  1p33
• Discovery year
  2014-06-05
• Entrez gene record
  729041
• Pubmed identfication
  • 30929760
• RefSeq identity
  • NR_045483
• VEGA ID
  OTTHUMG00000007812

Gene info

• Identity
  HGNC:32878
• Gene
  MIR622
• Long gene name
  microRNA 622
• Synonyms gene
  • MIRN622
• Synonyms
  • hsa-mir-622
• Locus
  13q31.3
• Discovery year
  2006-05-17
• Entrez gene record
  693207
• RefSeq identity
  • NR_030754
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:21197
• Gene
  FA2H
• Long gene name
  fatty acid 2-hydroxylase
• Synonyms gene
  • FAXDC1
  • SPG35
• Synonyms gene name
  • fatty acid hydroxylase domain containing 1
  • spastic paraplegia 35 (autosomal recessive)
• Synonyms
  • FAAH
  • FLJ25287
• Synonyms name
  • fatty acid hydroxylase
• GenBank acession
  • BC002679
• Locus
  16q23.1
• Discovery year
  2003-05-27
• Entrez gene record
  79152
• Pubmed identfication
  • 20104589
• RefSeq identity
  • NM_024306
• Classification
  • Fatty acid hydroxylase domain containing
• VEGA ID
  OTTHUMG00000137603

Gene info

• Identity
  HGNC:26440
• Gene
  FAAH2
• Long gene name
  fatty acid amide hydrolase 2
• Synonyms gene
  • AMDD
• Synonyms gene name
  • amidase domain containing
• Synonyms
  • RP11-479E16.1
  • FLJ31204
  • FAAH-2
• GenBank acession
  • AK055766
• Locus
  Xp11.21
• Discovery year
  2006-07-11
• Entrez gene record
  158584
• Pubmed identfication
  • 17015445
• RefSeq identity
  • NM_174912
• VEGA ID
  OTTHUMG00000021684
• Locus Specific Databases
  • Global Variome shared LOVD

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