IKK16

• Catalog number
  B1087-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  [4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone, hydrochloride
• Description
  IKK-16 is a potent and selective inhibitor of IκB kinase (IKK) with IC₅₀ values from 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. It is effective in cells and in animals and has been used delineate the role of NF-κB signaling in diverse contexts. IKK-16 has also been reported to inhibit protein kinase D isoforms and the ATP-binding cassette (ABC) transporter ABCB1.
• CAS Number
  1186195-62-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₈H₃₀ClN₅OS
• Molecular Weight
  520.09
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  IKK-16 is a potent and selective inhibitor of IκB kinase (IKK)
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD09971091
• PubChem CID
  56972179
• PubChem CID Link
• SMILES
  C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl
• InChi
  InChI=1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H
• InChi Key
  XFVDIVQCZWDBCW-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  IKK16  
• Short name
  IKK16
• Alternative name
  IKK16

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