anti- FAS/CD95 antibody

• Catalog number
  FNab03016
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
• Immunogen
  Fas (TNF receptor superfamily, member 6)
• Synonyms
  ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6
• Calculated MW
  Refer to figures
• Uniprot ID
  P25445
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
• Image1
  Immunohistochemistry of paraffin-embedded human prostate cancer using FNab03016(FAS antibody) at dilution of 1:100
• Image4
  HeLa cells were subjected to SDS PAGE followed by western blot with FNab03016(FAS antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FAS/CD95  
• Gene symbol
  FAS, FAS-AS1, FASN
• Short name
  anti- FAS/CD95 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- Fas (tumor necrosis factor receptor superfamily, member 6)/CD95 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  Fas (TNF receptor superfamily, member 6), ALPS1A and APO-1 and APT1 and CD95 and FAS1 and FASTM and TNFRSF6, FAS and IDBG-81669 and ENSG00000026103 and 355, identical protein binding, nuclei, Fas and IDBG-159577 and ENSMUSG00000024778 and 14102, FAS and IDBG-637356 and ENSBTAG00000010785 and 282488

Gene info

• Identity
  HGNC:11920
• Gene
  FAS
• Long gene name
  Fas cell surface death receptor
• Synonyms gene
  • FAS1
  • APT1
  • TNFRSF6
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 6
  • Fas (TNF receptor superfamily, member 6)
• Synonyms
  • CD95
  • APO-1
• Synonyms name
  • TNF receptor superfamily member 6
• GenBank acession
  • M67454
• Locus
  10q23.31
• Discovery year
  1992-06-25
• Entrez gene record
  355
• Pubmed identfication
  • 1385299
  • 1385309
• Classification
  • Tumor necrosis factor receptor superfamily
  • Death inducing signaling complex
  • CD molecules
• VEGA ID
  OTTHUMG00000018701
• Locus Specific Databases
  • Autoimmune Lymphoproliferative Syndrome Database (ALPSbase): Database of mutations causing human ALPS
  • LOVD at NCBI
  • LRG_134

Gene info

• Identity
  HGNC:37128
• Gene
  FAS-AS1
• Long gene name
  FAS antisense RNA 1
• Synonyms gene
  • FASAS
  • FAS-AS
• Synonyms gene name
  • FAS antisense RNA (non-protein coding)
  • FAS antisense RNA 1 (non-protein coding)
• Synonyms
  • SAF
• Locus
  10q23.31
• Discovery year
  2009-07-16
• Entrez gene record
  100302740
• Pubmed identfication
  • 15829500
  • 24811343
  • 27141526
• RefSeq identity
  • NR_028371
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:3594
• Gene
  FASN
• Long gene name
  fatty acid synthase
• Synonyms
  • FAS
  • SDR27X1
• Synonyms name
  • short chain dehydrogenase/reductase family 27X, member 1
• GenBank acession
  • U26644
• Locus
  17q25.3
• Discovery year
  1994-05-17
• Entrez gene record
  2194
• Pubmed identfication
  • 7835891
  • 7567999
  • 19027726
• RefSeq identity
  • NM_004104
• Classification
  • Short chain dehydrogenase/reductase superfamily
  • 7BS orphan methyltransferases
• VEGA ID
  OTTHUMG00000178527

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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