anti-ATM Antibody [3E8]
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Catalog number48-835
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PricePlease ask
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Size0.05 mg
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Gene infoATM-3E8 recognizes full-length ATM, a 370 kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation. The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.
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Gene namesATM, A-T mutated, ATA, ATC, ATD, ATE, AT mutated, Ataxia telangiectasia, ATDC, Serine-protein kinase ATM, AT1, Ataxia telangiectasia mutated, TEL1, TELO1
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Antibodie s labelunlabelled serum
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PurityProtein G Column
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Ab raised inMouse
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TypeMonoclonal
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Monoclonal[3E8]
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ImmunoglobulinIgG1
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AntigenATM monoclonal antibody was made against recombinant protein expressed in E. coli, amino acids 980 - 1512 of ATM (Human).
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Immuno applicationWestern Blot, immuno-histo-chemistry, immuno precipitation
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Antibody adviceATM antibody can be used in ELISA starting at 1:200 - 1:1000, Western Blot starting at 1:100 - 1:300, immunocytochemistry starting at 1:75, and immunofluorescence starting at 1:25 - 1:50.
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Suspention pH azidePBS, pH 7.4. No preservatives added.
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Keep atStore ATM antibody at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works withHuman
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Omim nr575773389
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Ncbi nrQ13315
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Vial with antibodyin solution
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NCBI GENE nr472
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GENE symbolATM
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Antigene nameataxia telangiectasia mutated
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SourceHomo sapiens
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Protein nrQ13315
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolATM
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Short nameanti-ATM Antibody [3E8]
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toATM (antibody to-) [3E8]
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Alternative techniqueantibodies
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Alternative to gene targetataxia telangiectasia mutated, AT1 and ATA and ATC and ATD and ATDC and ATE and TEL1 and TELO1, ATM and IDBG-70193 and ENSG00000149311 and 472, transferase activity, nuclei, Atm and IDBG-165511 and ENSMUSG00000034218 and 11920, ATM and IDBG-629882 and ENSBTAG00000003111 and 526824
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Gene info
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Identity
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Gene
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Long gene nameATM serine/threonine kinase
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Synonyms gene
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Synonyms gene name
- ataxia telangiectasia mutated (includes complementation groups A, C and D)
- ataxia telangiectasia mutated
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-07-07
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Entrez gene record
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RefSeq identity
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Classification
- Armadillo like helical domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
