UPK3A, human recombinant

• Catalog number
  7188-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A
• Alternative_names
  Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A
• Description
  Immunohistochemical marker for primary and metastatic urothelial carcinomas
• Recombinant
  Yes
• Source
  E. Coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Molecular Weight
  23.1 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Liquid
• Physical form description
  Sterile filtered colorless solution of 0.25 mg/ml containing 20 mM Tris-HCl buffer (pH 8.0), 150 mM NaCl, 2 mM DTT and 20% glycerol.
• Background Information
  UPK3A is a member of the uroplakin-3 family. Uroplakins (UP) which are transmembrane proteins are important components of the urothelium that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both members of the "tetraspanin" family). All hold great luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic shares in their C-termini. UPK3A is an extremely specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Alterations in this gene are related to renal adysplasia.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  UPK3A  
• Gene symbol
  UPK3A
• Short name
  UPK3A, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  UPK3A, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:12580
• Gene
  UPK3A
• Long gene name
  uroplakin 3A
• Synonyms gene
  • UPK3
• Synonyms gene name
  • uroplakin 3
• GenBank acession
  • AB010637
• Locus
  22q13.31
• Discovery year
  1992-07-31
• Entrez gene record
  7380
• Pubmed identfication
  • 9818021
• RefSeq identity
  • NM_006953
• VEGA ID
  OTTHUMG00000151339

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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