BCA-1/BLC (CXCL13), human recombinant

• Catalog number
  4001-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  B cell Attracting Chemokine-1, CXCL13, BLC (mouse), BLR1 Ligand
• Alternative_names
  B cell Attracting Chemokine-1, CXCL13, BLC (mouse), BLR1 Ligand, Angie, B lymphocyte chemoattractant, CXC chemokine BLC, Small-inducible cytokine B13
• Description
  A cytokine selectively chemotactic for B cells
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Biological activity
  Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10 ng/ml.
• Results
  1.0-10 ng/ml.
• Molecular Weight
  10.1 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and lyophilized from 10 mM TFA
• Reconstitution Instructions
  Centrifuge the vial prior to opening. Reconstitute in H₂O to a concentration of 0.1-1 mg/ml. The solution can then be diluted into other aqueous buffers or store at 4°C for 1 week or -20°C for future use.
• Background Information
  Human BCA-1 (B Cell-Attracting chemokine 1), also known as BLC or CXCL13, is a recently identified new CXC chemokines. Human BCA-1 is a highly effective attractant for human blood B lymphocytes, but was inactive on freshly isolated or IL-2 stimulated T lymphocytes, monocytes and neutrophils. The human BCA-1 is a 10.1 kDa protein containing 85 amino acid residues.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  BCA-1/BLC   CXCL13  
• Gene symbol
  CXCL13, BLNK, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR1289-1, MIR101-1, MIR16-1
• Short name
  BCA-1/BLC (CXCL13), recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Bicinchoninic acid-1/BLC (chemokine (C-X-C motif) ligand 13), H. sapiens Rec.
• Alternative technique
  rec
• Alternative to gene target
  chemokine (C-X-C motif) ligand 13, ANGIE and ANGIE2 and BCA-1 and BCA1 and BLC and BLR1L and SCYB13, CXCL13 and IDBG-25774 and ENSG00000156234 and 10563, CXCR3 chemokine receptor binding, Extracellular, Cxcl13 and IDBG-181227 and ENSMUSG00000023078 and 55985, CXCL13 and IDBG-643139 and ENSBTAG00000008479 and 511674

Gene info

• Identity
  HGNC:10639
• Gene
  CXCL13
• Long gene name
  C-X-C motif chemokine ligand 13
• Synonyms gene
  • SCYB13
• Synonyms gene name
  • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
  • chemokine (C-X-C motif) ligand 13
• Synonyms
  • BLC
  • BCA-1
  • BLR1L
  • ANGIE
  • ANGIE2
• Synonyms name
  • B-cell chemoattractant
• GenBank acession
  • AJ002211
• Locus
  4q21.1
• Discovery year
  2000-09-05
• Entrez gene record
  10563
• Pubmed identfication
  • 9463416
  • 9486651
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000130201

Gene info

• Identity
  HGNC:14211
• Gene
  BLNK
• Long gene name
  B cell linker
• Synonyms
  • SLP65
  • Ly57
  • SLP-65
  • BLNK-s
  • BASH
  • bca
• Synonyms name
  • B-cell adapter containing a SH2 domain protein
  • B-cell activation
  • Src homology [SH2] domain-containing leukocyte protein of 65 kD
  • B cell adaptor containing SH2 domain
• GenBank acession
  • AF068180
• Locus
  10q24.1
• Discovery year
  2001-07-16
• Entrez gene record
  29760
• Pubmed identfication
  • 9697839
  • 10583958
• RefSeq identity
  • NM_013314
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000018827
• Locus Specific Databases
  • BLNKbase: Mutation registry for BLNK deficiency
  • LRG_21

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:5760
• Gene
  IGKV1OR2-1
• Long gene name
  immunoglobulin kappa variable 1/OR2-1 (pseudogene)
• Synonyms gene
  • IGKVPZ1
  • IGKV1OR-1
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR-1
  • immunoglobulin kappa variable 1/OR-1 pseudogene
  • immunoglobulin kappa variable 1/OR-1 (pseudogene)
• Synonyms
  • IGKV1/OR-1
  • IGKV1/OR2-1
• GenBank acession
  • Z12367
• Locus
  2p11.1
• Discovery year
  2000-04-18
• Entrez gene record
  3531
• Pubmed identfication
  • 2853098
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000155081

Gene info

• Identity
  HGNC:35281
• Gene
  MIR1289-1
• Long gene name
  microRNA 1289-1
• Synonyms gene
  • MIRN1289-1
• Synonyms
  • hsa-mir-1289-1
• Locus
  20q11.22
• Discovery year
  2008-11-03
• Entrez gene record
  100302125
• RefSeq identity
  • NR_031620
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:31488
• Gene
  MIR101-1
• Long gene name
  microRNA 101-1
• Synonyms gene
  • MIRN101-1
• Synonyms
  • hsa-mir-101-1
• Locus
  1p31.3
• Discovery year
  2004-04-23
• Entrez gene record
  406893
• RefSeq identity
  • NR_029516
• Classification
  • MicroRNA MIR101 family

Gene info

• Identity
  HGNC:31545
• Gene
  MIR16-1
• Long gene name
  microRNA 16-1
• Synonyms gene
  • MIRN16-1
• Synonyms
  • hsa-mir-16-1
• Locus
  13q14.2
• Discovery year
  2004-04-23
• Entrez gene record
  406950
• RefSeq identity
  • NR_029486
• Classification
  • MicroRNA MIR15/16 family

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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